Insulin receptor
From Proteopedia
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<StructureSection load='3bu5' size='350' side='right' caption='Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (cyan), Mg+2 ion (green) and ATP (PDB entry [[3bu5]])' scene='51/516456/Cv/1'> | <StructureSection load='3bu5' size='350' side='right' caption='Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (cyan), Mg+2 ion (green) and ATP (PDB entry [[3bu5]])' scene='51/516456/Cv/1'> | ||
== Function == | == Function == | ||
| - | '''Insulin receptor''' (IR) is a transmembrane receptor activated by insulin, insulin-like growth factor I and II<ref>PMID:8141246</ref>. The IR is a dimer where each monomer contains 8 distinct domains. The β-chain contains a tyrosine kinase catalytic domain (TK). For more details see [[Student Projects for UMass Chemistry 423 Spring 2012-1]].<br /> | + | '''Insulin receptor''' (IR) is a transmembrane receptor activated by insulin, insulin-like growth factor I and II<ref>PMID:8141246</ref>. The IR is a dimer where each monomer contains 8 distinct domains. Residues 28-337 are the L1-CR domain. The β-chain contains a tyrosine kinase catalytic domain (TK) residues 1005-1310. For more details see [[Student Projects for UMass Chemistry 423 Spring 2012-1]].<br /> |
== Disease == | == Disease == | ||
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[[4xst]] – hIR L1-CR domains <br /> | [[4xst]] – hIR L1-CR domains <br /> | ||
[[2mfr]] – hIR transmembrane domain - NMR<br /> | [[2mfr]] – hIR transmembrane domain - NMR<br /> | ||
| + | [[5j3h]] – hIR L1-CR domains + antibody + peptide<br /> | ||
| + | [[4xss]] – hIR L1-CR domains + insulin-like growth factor 1<br /> | ||
[[4xlv]] - hIR TK domain (mutant) + ATP derivative<br /> | [[4xlv]] - hIR TK domain (mutant) + ATP derivative<br /> | ||
[[1ir3]] - hIR TK domain (mutant) + ATP analog + peptide<br /> | [[1ir3]] - hIR TK domain (mutant) + ATP analog + peptide<br /> | ||
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[[2auh]] – hIR TK domain + growth factor receptor-bound protein 14<br /> | [[2auh]] – hIR TK domain + growth factor receptor-bound protein 14<br /> | ||
[[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br /> | [[2b4s]] - hIR TK domain + tyrosine-protein phosphatase<br /> | ||
| - | [[1rqq]] – hIR TK domain (mutant) + adaptor protein PS | + | [[1rqq]] – hIR TK domain (mutant) + adaptor protein PS<br /> |
| + | [[6ce7]], [[6ce9]], [[6ceb]] – hIR + insulin <br /> | ||
| + | [[5kqv]] – hIR + insulin + antibody<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:01, 22 July 2018
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3D structures of insulin receptor
1irk – hIR TK domain – human
1i44, 1p14 – hIR TK domain (mutant)
2hr7 – hIR domains 1-3
4xst – hIR L1-CR domains
2mfr – hIR transmembrane domain - NMR
5j3h – hIR L1-CR domains + antibody + peptide
4xss – hIR L1-CR domains + insulin-like growth factor 1
4xlv - hIR TK domain (mutant) + ATP derivative
1ir3 - hIR TK domain (mutant) + ATP analog + peptide
3bu5, 3bu6 - hIR TK domain + ATP + peptide
3bu3 - hIR TK domain + peptide
1gag, 2z8c - hIR TK domain (mutant) + peptide
3ekk, 3ekn, 4ibm, 5hhw - hIR TK domain (mutant) + inhibitor
3eta, 5e1s - hIR TK domain + inhibitor
4zxb - hIR ectodomain (mutant) + antibody
2auh – hIR TK domain + growth factor receptor-bound protein 14
2b4s - hIR TK domain + tyrosine-protein phosphatase
1rqq – hIR TK domain (mutant) + adaptor protein PS
6ce7, 6ce9, 6ceb – hIR + insulin
5kqv – hIR + insulin + antibody
References
- ↑ Lee J, Pilch PF. The insulin receptor: structure, function, and signaling. Am J Physiol. 1994 Feb;266(2 Pt 1):C319-34. PMID:8141246
- ↑ Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem. 2008 Feb;114(1):23-37. doi: 10.1080/13813450801969715 . PMID:18465356 doi:http://dx.doi.org/10.1080/13813450801969715
- ↑ Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol. 2008 Mar;15(3):251-8. Epub 2008 Feb 17. PMID:18278056 doi:10.1038/nsmb.1388
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