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T-cell receptor

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Line 18: Line 18:
**[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br />
**[[1ac6]], [[1b88]], [[1h5b]], [[1i9e]] – mTCR α chain variable domain - mouse<br />
 +
**[[4udt]] – hTCR α chain variable domain + TRBV7-9 - human<br />
 +
**[[4udu]] – hTCR α chain variable domain + TRBV7-9 + enterotoxin type E<br />
*TCR β chain
*TCR β chain
**[[1bec]] – mTCR β chain <br />
**[[1bec]] – mTCR β chain <br />
-
**[[2axh]] – hTCR β chain (mutant) - human<br />
+
**[[2axh]] – hTCR β chain (mutant) <br />
**[[2axj]] – hTCR β chain <br />
**[[2axj]] – hTCR β chain <br />
**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br />
**[[2apb]], [[2apf]], [[2apt]], [[2apv]], [[2apw]], [[2apx]] – TCR β chain (mutant) - rat<br />
Line 39: Line 41:
**[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br />
**[[1tcr]], [[2z35]], [[2p1y]] – mTCR α+β chains<br />
-
**[[1tcr]], [[2q86]] – mTCR α+β chains (mutant)<br />
+
**[[1tcr]], [[2q86]], [[5iw1]]– mTCR α+β chains (mutant)<br />
**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />
**[[1bwm]] – mTCR α+β chains variable domains (mutant) - NMR<br />
-
**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]] – hTCR α+β chains<br />
+
**[[1kgc]], [[2nw2]], [[2vlm]], [[3dx9]], [[3mff]], [[3qeu]], [[3skn]], [[4dzb]], [[4e42]], [[4jfh]], [[4g8f]], [[4g8e]], [[4ww1]], [[4x6b]], [[4zdh]] – hTCR α+β chains<br />
**[[4ei6]] – h/mTCR α+β chains <br />
**[[4ei6]] – h/mTCR α+β chains <br />
**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />
**[[2ial]], [[4gg8]], [[4onh]] – hTCR α+β chains (mutant)<br />
Line 58: Line 60:
**[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br />
**[[1nfd]], [[1kb5]] – mTCR α+β chains + FAB fragment<br />
-
**[[2xna]] – hTCR α+β chains + enterotoxin <br />
+
**[[2xna]], [[5fk9]], [[5fka]] – hTCR α+β chains + enterotoxin <br />
 +
**[[5tl5]], [[5tlj]], [[5tlk]] – h/mTCR α+β chains + CD27 antigen <br />
*TCR complex with MHC and antigen
*TCR complex with MHC and antigen
-
**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
+
**[[1ao7]], [[1bd2]], [[1qrn]], [[1qse]], [[1qsf]], [[1mi5]], [[1oga]], [[1lp9]], [[2bnq]], [[2bnr]], [[2bnu]], [[2ak4]], [[2esv]], [[2f53]], [[2f54]], [[2gj6]], [[2nx5]], [[2p5e]], [[2p5w]], [[2pye]], [[2pyf]], [[3dxa]], [[3hg1]], [[3gsn]], [[3kpr]], [[3kps]], [[3kxf]], [[3o4l]], [[3qdg]], [[3qdj]], [[3qdm]], [[3qeq]], [[3sjv]], [[2ypl]], [[4jff]], [[4jfe]], [[4jfd]], [[4jry]], [[4jrx]], [[2jcc]], [[3d39]], [[3d3v]], [[4mji]], [[4prh]], [[4pri]], [[4prp]], [[5brz]], [[5bs0]], [[5c07]], [[5c08]], [[5c09]], [[5c0a]], [[5c0b]], [[5c0c]], [[5e6i]], [[5eu6]], [[5hhm]], [[5hho]], [[5hyj]], [[5ivx]], [[5ks9]], [[5ksa]], [[5ksb]], [[5m01]], [[5w1v]], [[5w1w]], [[5wkf]], [[5wkh]] – hTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br />
**[[4nqc]], [[4nqd]], [[4nqe]] – hTCR α+β chains + MHC + β-2 microglobulin + antigen <br />
**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br />
**[[1fyt]], [[1ymm]], [[1zgl]], [[4e41]], [[4z7u]], [[4z7v]], [[4z7w]] – hTCR α+β chains + MHC + polypeptide <br />
**[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
**[[4ozf]], [[4ozg]], [[4ozh]], [[4ozi]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
-
**[[3o6f]] – hTCR α+β chains + MHC <br />
+
**[[3o6f]], [[5u16]], [[5u17]] – hTCR α+β chains + MHC <br />
**[[3pl6]] – hTCR α chain + MHC + polypeptide <br />
**[[3pl6]] – hTCR α chain + MHC + polypeptide <br />
**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br />
**[[2xn9]], [[4c56]] – hTCR α+β chains + MHC + polypeptide + enterotoxin<br />
Line 72: Line 75:
**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
**[[2iam]], [[2ian]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
**[[1j8h]], [[4gg6]] – hTCR α+β chains (mutant) + MHC + polypeptide <br />
-
**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />
+
**[[5xov]] – hTCR δ+β chains + MHC + β-2 microglobulin + polypeptide <br />
-
**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
+
**[[4l4t]], [[4l4v]], [[4l8s]], [[4l9l]], [[4lcc]], [[4lcw]], [[5u1r]], [[5u2v]], [[5u6q]], [[5u72]] – hTCR MAIT α+β chains + MHC + β-2 microglobulin <br />
 +
**[[2ckb]], [[1fo0]], [[1g6r]], [[1kj2]], [[1mwa]], [[1nam]], [[2ol3]], [[2j8u]], [[5til]], [[5tje]] – mTCR α+β chains + MHC + β-2 microglobulin + polypeptide <br />
**[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br />
**[[4p2o]], [[4p2q]], [[4p2r]], [[4p46]] – mTCR α+β chains + MHC + polypeptide <br />
**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />
**[[2pxy]] – mTCR α+β chains (mutant) + MHC + β-2 microglobulin + polypeptide <br />
Line 81: Line 85:
**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />
**[[1ypz]] – hTCR γ+δ chains + MHC + β-2 microglobulin <br />
-
*TCR complex with CD1D
+
*TCR complex with CD1
-
**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
+
**[[4x6c]], [[4x6d]] – hTCR α+β chains + β-2 microglobulin + CD1A <br />
 +
**[[5wki]] – hTCR α+β chains + β-2 microglobulin + CD1B <br />
 +
**[[3huj]], [[3vwj]], [[3vwk]], [[4en3]], [[4ww2]], [[4wwk]] – hTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br />
**[[3tzv]] – hTCR NKT α+β chains (mutant) + β-2 microglobulin + CD1D <br />
-
**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
+
**[[3o8x]], [[3o9w]], [[4ei5]], [[4y16]], [[4y2d]], [[4y4h]], [[4y4k]], [[4y4f]], [[4zak]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D <br />
**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br />
**[[3scm]], [[3sda]], [[3sdc]], [[3sdd]], [[3sdx]] – h/mTCR NKT α+β chains + β-2 microglobulin + CD1D + ceramide derivative<br />

Revision as of 11:33, 6 November 2017

T-cell receptor α chain (deepskyblue), β chain (green) complex with enterotoxin (pink), glycerol and Na+ ion (purple) 2xna.

Drag the structure with the mouse to rotate

3D structures of T-cell receptor

Updated on 06-November-2017

References

  1. ↑ Kang L, Sebastian BM, Pritchard MT, Pratt BT, Previs SF, Nagy LE. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res. 2007 Sep;31(9):1581-8. Epub 2007 Jul 11. PMID:17624994 doi:http://dx.doi.org/10.1111/j.1530-0277.2007.00452.x
  2. ↑ Uttenthal BJ, Chua I, Morris EC, Stauss HJ. Challenges in T cell receptor gene therapy. J Gene Med. 2012 Jun;14(6):386-99. doi: 10.1002/jgm.2637. PMID:22610778 doi:http://dx.doi.org/10.1002/jgm.2637

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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