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GP1 of Lassa Virus
From Proteopedia
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==Importance== | ==Importance== | ||
| - | Lassa virus, an Old World [https://en.wikipedia.org/wiki/Arenavirus arenavirus], is a notorious disease-causing agent primarily in West Africa that is able to spread to rodents, as well as humans. This deadly pathogen causes severe viral hemorrhagic fevers and significant mortality. So far, there are no available vaccines for Lassa virus or any other diseases found in the ''Arenaviridae'' family. | + | Lassa virus, an Old World [https://en.wikipedia.org/wiki/Arenavirus arenavirus], is a notorious disease-causing agent primarily in West Africa that is able to spread to rodents, as well as humans. This deadly pathogen causes severe viral hemorrhagic fevers and significant mortality. So far, there are no available vaccines for Lassa virus or any other diseases found in the ''Arenaviridae'' family. Determining the structure of the complete trimeric glycoprotein complex, composed of GP!, GP2 and SSP (stable signal peptide), will lay the foundation for a future discovery of novel antiviral drugs. |
== Function == | == Function == | ||
Revision as of 08:05, 25 June 2017
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References
You may include any references to papers as in: the use of JSmol in Proteopedia [2] or to the article describing Jmol [3] to the rescue.
- ↑ Cohen-Dvashi H, Cohen N, Israeli H, Diskin R. Molecular mechanism for LAMP1 recognition by Lassa Virus. J Virol. 2015 May 13. pii: JVI.00651-15. PMID:25972533 doi:http://dx.doi.org/10.1128/JVI.00651-15
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Categories: Cohen, N | Cohen-Dvashi, H | Diskin, R | Israeli, H | Arenaviruse | Glycoprotein | Lassa | Receptor binding | Viral protein | 4zjf
