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Ire1

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== Structural highlights ==
== Structural highlights ==
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Yeast Ire1 structure contains 3 phosphorylated residues: <scene name='51/516469/Cv/2'>2 Ser and a Thr</scene>. Ire1 shows a different <scene name='51/516469/Cv/6'>binding site for ADP</scene> and for quercetin. Quercetin is a powerful activator of Ire1. <scene name='51/516469/Cv/8'>Ire1 binds 2 molecules of quercetin at its dimer interface</scene><ref>PMID:23880584</ref>.
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Yeast Ire1 structure contains 3 phosphorylated residues: <scene name='51/516469/Cv/9'>2 Ser and a Thr</scene>. Ire1 shows a different <scene name='51/516469/Cv/10'>binding site for ADP</scene> and for quercetin. Quercetin is a powerful activator of Ire1. <scene name='51/516469/Cv/11'>Ire1 binds 2 molecules of quercetin at its dimer interface</scene><ref>PMID:23880584</ref>.
==3D structures of Ire1==
==3D structures of Ire1==

Revision as of 13:09, 29 May 2019

Structure of yeast Ire1 cytoplasmic domain dimer complex with quercetin, ADP, Ca+2 and Sr+2 ions (PDB entry 3lj0)

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Michal Harel, Alexander Berchansky

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