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GP1 of Lassa Virus
From Proteopedia
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=== Histidine Triad=== | === Histidine Triad=== | ||
| - | Attached to this structure is a <scene name='76/761695/Histriad/2'>unique triad of histidines</scene> | + | Attached to this structure is a <scene name='76/761695/Histriad/2'>unique triad of histidines</scene>that is highly conserved among Old World arenaviruses. |
| + | This histidine triad forms part of the [[LAMP1]]-binding site. | ||
Forming on the [[LAMP1]]-binding site(insert scene), the histidine triad provides a molecular mechanism for the pH-dependent receptor switching. The histidine triad is shown to be necessary for interaction with LAMP1. | Forming on the [[LAMP1]]-binding site(insert scene), the histidine triad provides a molecular mechanism for the pH-dependent receptor switching. The histidine triad is shown to be necessary for interaction with LAMP1. | ||
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== References == | == References == | ||
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<references/> | <references/> | ||
Revision as of 07:21, 26 June 2017
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References
- ↑ Cohen-Dvashi H, Cohen N, Israeli H, Diskin R. Molecular mechanism for LAMP1 recognition by Lassa Virus. J Virol. 2015 May 13. pii: JVI.00651-15. PMID:25972533 doi:http://dx.doi.org/10.1128/JVI.00651-15
Categories: Cohen, N | Cohen-Dvashi, H | Diskin, R | Israeli, H | Arenaviruse | Glycoprotein | Lassa | Receptor binding | Viral protein | 4zjf
