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GP1 of Lassa Virus

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==Structural Highlights==
==Structural Highlights==
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Protein structure accession number: '''4ZJF'''. 4ZJF is a 4 chain structure with <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> ligands attached to each chain. The overall architecture of GP1 features a central β-sheet and two distinct halves: a glycosylated half containing the receptor-binding site that is made mostly by the central β-sheet and surrounding loops and a half that contains mostly helices and most likely faces the trimer axis<ref>DOI 10.1128/JVI.00651-15</ref>..
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Protein structure accession number: '''4ZJF'''. 4ZJF is a 4 chain structure with <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> ligands attached to each chain. The overall architecture of GP1 features a central β-sheet and two distinct halves: a glycosylated half containing the receptor-binding site that is made mostly by the central β-sheet and surrounding loops and a half that contains mostly helices and most likely faces the trimer axis<ref name="MolMechforLAMP1">DOI 10.1128/JVI.00651-15</ref>..
For more information on this protein structure visit the following sites: [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjf OCA], [http://pdbe.org/4zjf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjf RCSB], [http://www.ebi.ac.uk/pdbsum/4zjf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjf ProSAT]
For more information on this protein structure visit the following sites: [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjf OCA], [http://pdbe.org/4zjf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjf RCSB], [http://www.ebi.ac.uk/pdbsum/4zjf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjf ProSAT]
=== Histidine Triad===
=== Histidine Triad===
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Attached to this structure is a <scene name='76/761695/Histriad/4'>unique triad of histidines</scene> that is highly conserved among Old World arenaviruses.
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Attached to this structure is a <scene name='76/761695/Histriad/4'>unique triad of histidines</scene> that is highly conserved among Old World arenaviruses. The histidine triad is a structural element that directly interacts with [[LAMP1]] and helps stabilize a LAMP1-"compatible" conformation<ref name="MolMechforLAMP1" />.
This histidine triad forms part of the [[LAMP1]]-binding site.
This histidine triad forms part of the [[LAMP1]]-binding site.

Revision as of 08:11, 26 June 2017

4ZJF structure

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References

  1. ↑ 1.0 1.1 Cohen-Dvashi H, Cohen N, Israeli H, Diskin R. Molecular mechanism for LAMP1 recognition by Lassa Virus. J Virol. 2015 May 13. pii: JVI.00651-15. PMID:25972533 doi:http://dx.doi.org/10.1128/JVI.00651-15

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Rebecca Holstein, Michal Harel

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