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GP1 of Lassa Virus
From Proteopedia
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== Function == | == Function == | ||
| - | '''GP1''' (Glycoprotein 1) is the receptor binding domain of Lassa virus that mediates receptor recognition. | + | '''GP1''' (Glycoprotein 1) is the receptor binding domain of Lassa virus that mediates receptor recognition. |
==Structural Highlights== | ==Structural Highlights== | ||
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=== Histidine Triad=== | === Histidine Triad=== | ||
| - | Attached to this structure is a <scene name='76/761695/Histriad/4'>unique triad of histidines</scene> that is highly conserved among Old World arenaviruses. | + | Attached to this structure is a <scene name='76/761695/Histriad/4'>unique triad of histidines</scene> that is highly conserved among Old World arenaviruses. Located on the β-sheet face of GP1, the histidine triad is a structural element that directly interacts with [[LAMP1]] and helps stabilize a LAMP1-"compatible" conformation by providing a molecular mechanism for the pH-dependent receptor switching<ref name="MolMechforLAMP1" />. |
</StructureSection> | </StructureSection> | ||
Revision as of 08:26, 26 June 2017
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References
- ↑ 1.0 1.1 Cohen-Dvashi H, Cohen N, Israeli H, Diskin R. Molecular mechanism for LAMP1 recognition by Lassa Virus. J Virol. 2015 May 13. pii: JVI.00651-15. PMID:25972533 doi:http://dx.doi.org/10.1128/JVI.00651-15
Categories: Cohen, N | Cohen-Dvashi, H | Diskin, R | Israeli, H | Arenaviruse | Glycoprotein | Lassa | Receptor binding | Viral protein | 4zjf
