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GP1 of Lassa Virus

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'''GP1''' (Glycoprotein 1) is the receptor binding domain of Lassa virus that mediates receptor recognition. Research thus far indicates that GP1 from Lassa virus may undergo irreversible conformational changes that could serve as an immunological decoy mechanism.
'''GP1''' (Glycoprotein 1) is the receptor binding domain of Lassa virus that mediates receptor recognition. Research thus far indicates that GP1 from Lassa virus may undergo irreversible conformational changes that could serve as an immunological decoy mechanism.
==Structural Highlights==
==Structural Highlights==
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Protein structure accession number: '''4ZJF'''. 4ZJF is a 4 chain structure with <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> ligands attached to each chain. The overall architecture of GP1 features a central β-sheet and two distinct halves: a glycosylated half containing the receptor-binding site that is made mostly by the central β-sheet and surrounding loops and a half that contains mostly helices and most likely faces the trimer axis<ref name="MolMechforLAMP1">DOI 10.1128/JVI.00651-15</ref>. The method used to determine this structure was
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GP1 of Lassa virus is a 4 chain structure with <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> ligands attached to each chain. The overall architecture of GP1 features a central β-sheet and two distinct halves: a glycosylated half containing the receptor-binding site that is made mostly by the central β-sheet and surrounding loops and a half that contains mostly helices and most likely faces the trimer axis<ref name="MolMechforLAMP1">DOI 10.1128/JVI.00651-15</ref>. The method used to determine this structure was
[https://en.wikipedia.org/wiki/X-ray_crystallography X-ray diffraction]
[https://en.wikipedia.org/wiki/X-ray_crystallography X-ray diffraction]
=== Histidine Triad===
=== Histidine Triad===
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Recent studies show that receptor switching is critical during cell entry of Lassa virus. Receptor switching to LAMP1 is critical for triggering membrane fusion by Lassa virus.
Recent studies show that receptor switching is critical during cell entry of Lassa virus. Receptor switching to LAMP1 is critical for triggering membrane fusion by Lassa virus.
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Protein structure accession number: '''4ZJF'''
For more information on this protein structure visit the following sites: [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjf OCA], [http://pdbe.org/4zjf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjf RCSB], [http://www.ebi.ac.uk/pdbsum/4zjf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjf ProSAT]
For more information on this protein structure visit the following sites: [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjf OCA], [http://pdbe.org/4zjf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zjf RCSB], [http://www.ebi.ac.uk/pdbsum/4zjf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjf ProSAT]
</StructureSection>
</StructureSection>

Revision as of 07:16, 27 June 2017

4ZJF structure

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References

  1. ↑ 1.0 1.1 Cohen-Dvashi H, Cohen N, Israeli H, Diskin R. Molecular mechanism for LAMP1 recognition by Lassa Virus. J Virol. 2015 May 13. pii: JVI.00651-15. PMID:25972533 doi:http://dx.doi.org/10.1128/JVI.00651-15

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