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GP1 of Lassa Virus

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[https://en.wikipedia.org/wiki/X-ray_crystallography X-ray diffraction]
[https://en.wikipedia.org/wiki/X-ray_crystallography X-ray diffraction]
=== Histidine Triad===
=== Histidine Triad===
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Attached to this structure is a <scene name='76/761695/Histriad/5'>unique triad of histidines</scene> that is highly conserved among Old World arenaviruses. Located on the β-sheet face of GP1, the histidine triad is a structural element that directly interacts with [[LAMP1]] and helps stabilize a LAMP1-"compatible" conformation by providing a molecular mechanism for the pH-dependent receptor switching<ref name="MolMechforLAMP1" />. The binding of LAMP1 triggers the glycoprotein spike complex of
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Attached to this structure is a <scene name='76/761695/Histriad/5'>unique triad of histidines</scene> that is highly conserved among Old World arenaviruses. Located on the β-sheet face of GP1, the histidine triad is a structural element that directly interacts with [[LAMP1]] and helps stabilize a LAMP1-"compatible" conformation by providing a molecular mechanism for the pH-dependent receptor switching<ref name="MolMechforLAMP1" />. The binding of LAMP1 triggers the glycoprotein spike complex of LASV to catalyze [https://en.wikipedia.org/wiki/Lipid_bilayer_fusion membrane fusion] by potentiating its response to pH.
===LAMP1 Binding Site===
===LAMP1 Binding Site===
Recent studies show that receptor switching is critical during cell entry of LASV. Receptor switching to LAMP1 is critical for triggering membrane fusion by LASV.
Recent studies show that receptor switching is critical during cell entry of LASV. Receptor switching to LAMP1 is critical for triggering membrane fusion by LASV.

Revision as of 07:40, 27 June 2017

4ZJF structure

Drag the structure with the mouse to rotate

References

  1. ↑ 1.0 1.1 Cohen-Dvashi H, Cohen N, Israeli H, Diskin R. Molecular mechanism for LAMP1 recognition by Lassa Virus. J Virol. 2015 May 13. pii: JVI.00651-15. PMID:25972533 doi:http://dx.doi.org/10.1128/JVI.00651-15

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Rebecca Holstein, Michal Harel

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