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GP1 of Lassa Virus

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<StructureSection load='4zjf' size='340' side='right' caption='4ZJF structure' scene='76/761695/4zjf_chaina/2'>
<StructureSection load='4zjf' size='340' side='right' caption='4ZJF structure' scene='76/761695/4zjf_chaina/2'>
==Importance==
==Importance==
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<scene name='76/761695/5vk2on4zjf_histriad/2'>TextToBeDisplayed</scene>
Lassa virus (LASV), an Old World [https://en.wikipedia.org/wiki/Arenavirus arenavirus], is a notorious disease-causing agent primarily in West Africa that is able to spread to rodents, as well as humans. This deadly pathogen causes severe viral hemorrhagic fevers and significant mortality. So far, there are no available vaccines for LASV or any other viruses found in the ''Arenaviridae'' family. Determining the structure of the complete trimeric glycoprotein complex, composed of GP1, GP2, and SSP (stable signal peptide), will lay the foundation for a future discovery of novel antiviral drugs. This is the first representative structure for Old World arenaviruses.
Lassa virus (LASV), an Old World [https://en.wikipedia.org/wiki/Arenavirus arenavirus], is a notorious disease-causing agent primarily in West Africa that is able to spread to rodents, as well as humans. This deadly pathogen causes severe viral hemorrhagic fevers and significant mortality. So far, there are no available vaccines for LASV or any other viruses found in the ''Arenaviridae'' family. Determining the structure of the complete trimeric glycoprotein complex, composed of GP1, GP2, and SSP (stable signal peptide), will lay the foundation for a future discovery of novel antiviral drugs. This is the first representative structure for Old World arenaviruses.
== Function ==
== Function ==

Revision as of 12:49, 27 June 2017

4ZJF structure

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References

  1. ↑ 1.0 1.1 Cohen-Dvashi H, Cohen N, Israeli H, Diskin R. Molecular mechanism for LAMP1 recognition by Lassa Virus. J Virol. 2015 May 13. pii: JVI.00651-15. PMID:25972533 doi:http://dx.doi.org/10.1128/JVI.00651-15

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Rebecca Holstein, Michal Harel

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