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1vmp

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vmp OCA], [http://www.ebi.ac.uk/pdbsum/1vmp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vmp RCSB]</span>
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'''STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II'''
'''STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II'''
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[[Category: Sun, Y.]]
[[Category: Sun, Y.]]
[[Category: Wang, Z X.]]
[[Category: Wang, Z X.]]
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[[Category: chemokine]]
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[[Category: Chemokine]]
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[[Category: herpesvirus]]
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[[Category: Herpesvirus]]
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[[Category: hhv-8]]
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[[Category: Hhv-8]]
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[[Category: kaposis']]
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[[Category: Kaposis']]
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[[Category: monomer]]
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[[Category: Monomer]]
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[[Category: sarcoma]]
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[[Category: Sarcoma]]
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[[Category: vmip-ii]]
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[[Category: Vmip-ii]]
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Revision as of 09:43, 3 May 2008

Image:1vmp.jpg

Template:STRUCTURE 1vmp

STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II


Overview

We report the solution structure of the chemotactic cytokine (chemokine) vMIP-II. This protein has unique biological activities in that it blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors, some of which are used by HJV to gain cell entry. vMIP-II is a monomeric protein, unlike most members of the chemokine family, and its structure consists of a disordered N-terminus, followed by a helical turn (Gln25-Leu27), which leads into the first strand of a three-stranded antiparallel beta-sheet (Ser29-Thr34; Gly42-Thr47; Gln52-Asp56). Following the sheet is a C-terminal alpha-helix, which extends from residue Asp60 until Gln68. The final five residues beyond the C-terminal helix (Pro70-Arg74) are in an extended conformation, but several of these C-terminal residues contact the first beta-strand. The structure of vMIP-II is compared to other chemokines that also block infection by HIV-1, and the structural basis of its lack of ability to form a dimer is discussed.

About this Structure

1VMP is a Single protein structure of sequence from Human herpesvirus 8. Full crystallographic information is available from OCA.

Reference

The solution structure of the anti-HIV chemokine vMIP-II., Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ, Protein Sci. 1999 Nov;8(11):2270-80. PMID:10595530 Page seeded by OCA on Sat May 3 12:43:37 2008

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