1vp6
From Proteopedia
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[[Image:1vp6.jpg|left|200px]] | [[Image:1vp6.jpg|left|200px]] | ||
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'''M.loti ion channel cylic nucleotide binding domain''' | '''M.loti ion channel cylic nucleotide binding domain''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1VP6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. This structure supersedes the now removed PDB entry | + | 1VP6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1pf0 1pf0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VP6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Morais-Cabral, J H.]] | [[Category: Morais-Cabral, J H.]] | ||
[[Category: Silverman, W R.]] | [[Category: Silverman, W R.]] | ||
| - | [[Category: | + | [[Category: Dimer helical bundle beta barrel core with cyclic amp bound]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:45:09 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:45, 3 May 2008
M.loti ion channel cylic nucleotide binding domain
Overview
Here we describe the initial functional characterization of a cyclic nucleotide regulated ion channel from the bacterium Mesorhizobium loti and present two structures of its cyclic nucleotide binding domain, with and without cAMP. The domains are organized as dimers with the interface formed by the linker regions that connect the nucleotide binding pocket to the pore domain. Together, structural and functional data suggest the domains form two dimers on the cytoplasmic face of the channel. We propose a model for gating in which ligand binding alters the structural relationship within a dimer, directly affecting the position of the adjacent transmembrane helices.
About this Structure
1VP6 is a Single protein structure of sequence from Mesorhizobium loti. This structure supersedes the now removed PDB entry 1pf0. Full crystallographic information is available from OCA.
Reference
Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel., Clayton GM, Silverman WR, Heginbotham L, Morais-Cabral JH, Cell. 2004 Nov 24;119(5):615-27. PMID:15550244 Page seeded by OCA on Sat May 3 12:45:09 2008
