Tryptase inhibitor

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== Relevance ==
== Relevance ==
TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.
TI are used as anti-inflammatory agents in treating asthma and other airway inflammation diseases. Tryptase was found in elevated levels in various kinds of allergic inflammations.
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*<scene name='51/517374/Cv/2'>Tryptase inhibitor/trypsin interactions</scene> (PDB entry [[1ldt]]).
</StructureSection>
</StructureSection>

Revision as of 09:16, 11 July 2017

Structure of leech tryptase inhibitor (magenta) complex with trypsin (cyan) and Ca+2 ion (green) (PDB entry 1ldt)

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3D structures of tryptase inhibitor

Updated on 11-July-2017

References

  1. Stubbs MT, Morenweiser R, Sturzebecher J, Bauer M, Bode W, Huber R, Piechottka GP, Matschiner G, Sommerhoff CP, Fritz H, Auerswald EA. The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition. J Biol Chem. 1997 Aug 8;272(32):19931-7. PMID:9242660

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Michal Harel, Alexander Berchansky

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