1vpt

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[[Image:1vpt.jpg|left|200px]]
[[Image:1vpt.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1vpt |SIZE=350|CAPTION= <scene name='initialview01'>1vpt</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1vpt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1vpt| PDB=1vpt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vpt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vpt OCA], [http://www.ebi.ac.uk/pdbsum/1vpt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vpt RCSB]</span>
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}}
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'''AS11 VARIANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE'''
'''AS11 VARIANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE'''
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[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
[[Category: Shi, X.]]
[[Category: Shi, X.]]
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[[Category: methyltransferase]]
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[[Category: Methyltransferase]]
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[[Category: poly(a) polymerase]]
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[[Category: Rna cap]]
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[[Category: rna cap]]
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[[Category: Vaccinia]]
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[[Category: vaccinia]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:46:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:27:04 2008''
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Revision as of 09:46, 3 May 2008

Image:1vpt.jpg

Template:STRUCTURE 1vpt

AS11 VARIANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE


Overview

VP39 is a bifunctional vaccinia virus protein that acts as both an mRNA cap-specific RNA 2'-O-methyltransferase and a poly(A) polymerase processivity factor. Here, we report the 1.85 A crystal structure of a VP39 variant complexed with its AdoMet cofactor. VP39 comprises a single core domain with structural similarity to the catalytic domains of other methyltransferases. Surface features and mutagenesis data suggest two possible RNA-binding sites with novel underlying architecture, one of which forms a cleft spanning the region adjacent to the methyltransferase active site. This report provides a prototypic structure for an RNA methyltransferase, a protein that interacts with the mRNA 5' cap, and an intact poxvirus protein.

About this Structure

1VPT is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends., Hodel AE, Gershon PD, Shi X, Quiocho FA, Cell. 1996 Apr 19;85(2):247-56. PMID:8612277 Page seeded by OCA on Sat May 3 12:46:32 2008

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