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Metabotropic glutamate receptor
From Proteopedia
(Difference between revisions)
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**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br /> | **[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br /> | ||
**[[3sm9]] - hMGluR3 + antagonist<br /> | **[[3sm9]] - hMGluR3 + antagonist<br /> | ||
| - | **[[4xar]] – hMGluR3 LBD + agonist<br /> | + | **[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br /> |
**[[5cnm]] – hMGluR3 LBD + Glu analog<br /> | **[[5cnm]] – hMGluR3 LBD + Glu analog<br /> | ||
*Metabotropic glutamate receptor 5 | *Metabotropic glutamate receptor 5 | ||
| + | **[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br /> | ||
**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br /> | **[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br /> | ||
**[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br /> | **[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br /> | ||
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**[[5c5c]] – hMGluR7 LBD (mutant)<br /> | **[[5c5c]] – hMGluR7 LBD (mutant)<br /> | ||
**[[3mq4]] – hMGluR7 LBD + antagonist<br /> | **[[3mq4]] – hMGluR7 LBD + antagonist<br /> | ||
| + | |||
| + | *Metabotropic glutamate receptor 8 | ||
| + | |||
| + | **[[6bsz]] – hMGluR8 LBD + Glu <br /> | ||
| + | **[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br /> | ||
}} | }} | ||
==See Also== | ==See Also== | ||
Revision as of 09:51, 6 August 2018
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3D structures of metabotropic glutamate receptor
Updated on 06-August-2018
See Also
Membrane Channels & Pumps
Ionotropic_Glutamate_Receptors
Alzheimer's Disease
References
- ↑ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. PMID:20716669 doi:http://dx.doi.org/10.1124/pr.109.002451
- ↑ Johnson KA, Conn PJ, Niswender CM. Glutamate receptors as therapeutic targets for Parkinson's disease. CNS Neurol Disord Drug Targets. 2009 Dec;8(6):475-91. PMID:19702565
- ↑ Niswender CM, Conn PJ. Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol. 2010;50:295-322. doi:, 10.1146/annurev.pharmtox.011008.145533. PMID:20055706 doi:http://dx.doi.org/10.1146/annurev.pharmtox.011008.145533
- ↑ Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 2000 Oct 26;407(6807):971-7. PMID:11069170 doi:10.1038/35039564
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