Methylcitrate synthase
From Proteopedia
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<StructureSection load='3tag' size='350' side='right' caption='Methylcitrate synthase dimer (PDB entry [[3tag]])' scene=''> | <StructureSection load='3tag' size='350' side='right' caption='Methylcitrate synthase dimer (PDB entry [[3tag]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Methylcitrate synthase''' (MCS) participates in propanoate metabolism. It catalyzes the conversion of acyl to alkyl group in the reaction which converts propanoyl-CoA and oxaloacetate to 2-hydroxybutane-1,2,3-tricarboxylate and CoA<ref>PMID:10482501</ref>. The | + | '''Methylcitrate synthase''' (MCS) participates in propanoate metabolism. It catalyzes the conversion of acyl to alkyl group in the reaction which converts propanoyl-CoA and oxaloacetate to 2-hydroxybutane-1,2,3-tricarboxylate and CoA<ref>PMID:10482501</ref>. The metabolism of propionyl-CoA in microorganism is performed by the methylcitrate cycle. The methylcitrate cycle contains MCS, methylcitrate dehydrogenase and methylisocitrate lyase<ref>PMID:18048912</ref>. The methylcitrate cycle can serve as a carbon and energy source of growth. In the presence of glucose, the cycle serves to remove the toxic propionate. |
== Relevance == | == Relevance == | ||
Revision as of 07:10, 23 July 2017
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3D structures of methylcitrate synthase
3hwk – MCS – Mycobacterium tuberculosis
3o8j – MCS – Salmonella enterica
3tqg – MCS – Coxiella burnetii
References
- ↑ Horswill AR, Escalante-Semerena JC. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. J Bacteriol. 1999 Sep;181(18):5615-23. PMID:10482501
- ↑ Upton AM, McKinney JD. Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis. Microbiology. 2007 Dec;153(Pt 12):3973-82. PMID:18048912 doi:http://dx.doi.org/10.1099/mic.0.2007/011726-0
- ↑ Brock M, Fischer R, Linder D, Buckel W. Methylcitrate synthase from Aspergillus nidulans: implications for propionate as an antifungal agent. Mol Microbiol. 2000 Mar;35(5):961-73. PMID:10712680
