Myeloperoxidase

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<StructureSection load='1myp' size='350' side='right' caption='Dog glycosylated myeloperoxidase dimer: heavy chain (pink and yellow), light chain (grey and green) containing heme complex with Ca+2 ions (green) (PDB entry [[1myp]])' scene=''>
<StructureSection load='1myp' size='350' side='right' caption='Dog glycosylated myeloperoxidase dimer: heavy chain (pink and yellow), light chain (grey and green) containing heme complex with Ca+2 ions (green) (PDB entry [[1myp]])' scene=''>
== Function ==
== Function ==
Line 16: Line 15:
[[1myp]] – MPO – dog<br />
[[1myp]] – MPO – dog<br />
[[1mhl]], [[1cxp]] – hMPO C – human<br />
[[1mhl]], [[1cxp]] – hMPO C – human<br />
-
[[3f9p]] - hMPO<br />
+
[[3f9p]], [[5fiw]], [[5mfa]] - hMPO<br />
[[1qo4]] - MPO – ''Arabidopsis thaliana''<br />
[[1qo4]] - MPO – ''Arabidopsis thaliana''<br />
[[1d2v]] – hMPO C + Br<br />
[[1d2v]] – hMPO C + Br<br />
Line 23: Line 22:
[[1dnu]] - hMPO + SCN<BR />
[[1dnu]] - hMPO + SCN<BR />
[[1dnw]] - hMPO + CN + SCN<BR />
[[1dnw]] - hMPO + CN + SCN<BR />
-
[[3zs0]], [[3zs1]], [[4c1m]] - hMPO + inhibitor<br />
+
[[3zs0]], [[3zs1]], [[4c1m]], [[5uzu]] - hMPO + inhibitor<br />
[[4dl1]] - hMPO + thioxanthine<br />
[[4dl1]] - hMPO + thioxanthine<br />
[[4ejx]] - hMPO + ceruplasmin<br />
[[4ejx]] - hMPO + ceruplasmin<br />

Revision as of 09:23, 30 July 2017

Dog glycosylated myeloperoxidase dimer: heavy chain (pink and yellow), light chain (grey and green) containing heme complex with Ca+2 ions (green) (PDB entry 1myp)

Drag the structure with the mouse to rotate

3D structures of myeloperoxidase

Updated on 30-July-2017

1myp – MPO – dog
1mhl, 1cxp – hMPO C – human
3f9p, 5fiw, 5mfa - hMPO
1qo4 - MPO – Arabidopsis thaliana
1d2v – hMPO C + Br
1d5l – hMPO + CN
1d7w - hMPO + CN + Br
1dnu - hMPO + SCN
1dnw - hMPO + CN + SCN
3zs0, 3zs1, 4c1m, 5uzu - hMPO + inhibitor
4dl1 - hMPO + thioxanthine
4ejx - hMPO + ceruplasmin

References

  1. ↑ Klebanoff SJ. Myeloperoxidase. Proc Assoc Am Physicians. 1999 Sep-Oct;111(5):383-9. PMID:10519157
  2. ↑ Friedrich R, Fuentes-Prior P, Ong E, Coombs G, Hunter M, Oehler R, Pierson D, Gonzalez R, Huber R, Bode W, Madison EL. Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem. 2002 Jan 18;277(3):2160-8. Epub 2001 Nov 5. PMID:11696548 doi:10.1074/jbc.M109830200
  3. ↑ Malle E, Buch T, Grone HJ. Myeloperoxidase in kidney disease. Kidney Int. 2003 Dec;64(6):1956-67. PMID:14633118 doi:http://dx.doi.org/10.1046/j.1523-1755.2003.00336.x
  4. ↑ Lazarevic-Pasti T, Leskovac A, Vasic V. Myeloperoxidase Inhibitors as Potential Drugs. Curr Drug Metab. 2015;16(3):168-90. PMID:26279325

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Michal Harel, Alexander Berchansky

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