1vyb

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[[Image:1vyb.jpg|left|200px]]
[[Image:1vyb.jpg|left|200px]]
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{{Structure
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|PDB= 1vyb |SIZE=350|CAPTION= <scene name='initialview01'>1vyb</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1vyb", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|ACTIVITY=
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{{STRUCTURE_1vyb| PDB=1vyb | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vyb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vyb OCA], [http://www.ebi.ac.uk/pdbsum/1vyb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1vyb RCSB]</span>
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'''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P'''
'''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P'''
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[[Category: Repanas, K.]]
[[Category: Repanas, K.]]
[[Category: Weichenrieder, O.]]
[[Category: Weichenrieder, O.]]
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[[Category: ape-1 type]]
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[[Category: Ape-1 type]]
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[[Category: endonuclease]]
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[[Category: Endonuclease]]
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[[Category: retrotransposition]]
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[[Category: Retrotransposition]]
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[[Category: retrotransposon]]
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[[Category: Retrotransposon]]
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[[Category: rna-directed dna polymerase]]
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[[Category: Rna-directed dna polymerase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:54:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:28:40 2008''
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Revision as of 09:54, 3 May 2008

Image:1vyb.jpg

Template:STRUCTURE 1vyb

ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P


Overview

The human L1 endonuclease (L1-EN) is encoded by the non-LTR retrotransposon LINE-1 (L1). L1 is responsible for more than 1.5 million retrotransposition events in the history of the human genome, contributing more than a quarter to human genomic DNA (L1 and Alu elements). L1-EN is related to the well-understood human DNA repair endonuclease APE1, and its nicking specificity is a major determinant for retrotransposon integration site selection. The crystal structure of human L1 endonuclease is the first of a retrotransposon-encoded protein and a prototype for retrotransposon-encoded endonucleases involved in target-primed reverse transcription. Structure-based endonuclease alignments reveal a conserved threonine in addition to previously identified invariant residues and suggest that DNA recognition proceeds via the accommodation of an extrahelical nucleotide within a pocket of the enzyme. The present analysis will help to refine phylogenetic and functional relationships among metal-dependent phosphohydrolases and provides a basis for manipulating non-LTR retrotransposon integration site selection.

About this Structure

1VYB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon., Weichenrieder O, Repanas K, Perrakis A, Structure. 2004 Jun;12(6):975-86. PMID:15274918 Page seeded by OCA on Sat May 3 12:54:34 2008

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OCA

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