1w0d

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[[Image:1w0d.gif|left|200px]]
[[Image:1w0d.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w0d |SIZE=350|CAPTION= <scene name='initialview01'>1w0d</scene>, resolution 1.65&Aring;
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The line below this paragraph, containing "STRUCTURE_1w0d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-isopropylmalate_dehydrogenase 3-isopropylmalate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.85 1.1.1.85] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK03437 PRK03437]</span>
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{{STRUCTURE_1w0d| PDB=1w0d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w0d OCA], [http://www.ebi.ac.uk/pdbsum/1w0d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w0d RCSB]</span>
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}}
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'''THE HIGH RESOLUTION STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LEUB (RV2995C)'''
'''THE HIGH RESOLUTION STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LEUB (RV2995C)'''
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: TBSGC, TB Structural Genomics Consortium.]]
[[Category: Weiss, M S.]]
[[Category: Weiss, M S.]]
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[[Category: dehydrogenase,oxidoreductase,leucine biosynthesis,nad]]
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[[Category: Dehydrogenase,oxidoreductase,leucine biosynthesis,nad]]
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[[Category: structural genomics,psi,protein structure initiative]]
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[[Category: Structural genomics,psi,protein structure initiative]]
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[[Category: tb structural genomics consortium,tb]]
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[[Category: Tb structural genomics consortium,tb]]
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[[Category: tbsgc]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:59:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:29:24 2008''
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Revision as of 09:59, 3 May 2008

Image:1w0d.gif

Template:STRUCTURE 1w0d

THE HIGH RESOLUTION STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS LEUB (RV2995C)


Overview

The crystal structure of the enzyme 3-isopropylmalate dehydrogenase (IPMDH) from Mycobacterium tuberculosis (LeuB, Mtb-IPMDH, Rv2995c) without substrate or co-factor was determined at 1.65 A resolution, which is the highest resolution reported for an IPMDH to date. The crystals contain two functional dimers in the asymmetric unit in an arrangement close to a tetramer of D2 symmetry. Despite the absence of a substrate or inhibitor bound to the protein, the structure of the monomer resembles the previously observed closed form of the enzyme more closely than the open form. A comparison with the substrate complex of IPMDH from Thiobacillus ferrooxidans and the co-factor complex of the Thermus thermophilus enzyme revealed a close relationship of the active-site architecture between the various bacterial enzymes. The inhibitor O-isobutenyl oxalylhydroxamate was found to bind to the active site of IPMDH in a mode similar to the substrate isopropylmalate.

About this Structure

1W0D is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

The high-resolution Structure of LeuB (Rv2995c) from Mycobacterium tuberculosis., Singh RK, Kefala G, Janowski R, Mueller-Dieckmann C, von Kries JP, Weiss MS, J Mol Biol. 2005 Feb 11;346(1):1-11. Epub 2004 Dec 23. PMID:15663922 Page seeded by OCA on Sat May 3 12:59:21 2008

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