1w1i
From Proteopedia
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'''CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE''' | '''CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE''' | ||
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[[Category: Saenger, W.]] | [[Category: Saenger, W.]] | ||
[[Category: Weihofen, W A.]] | [[Category: Weihofen, W A.]] | ||
| - | [[Category: | + | [[Category: Ada]] |
| - | [[Category: | + | [[Category: Adenosine deaminase]] |
| - | [[Category: | + | [[Category: Alpha/beta-hydrolase fold]] |
| - | [[Category: | + | [[Category: Aminopeptidase]] |
| - | [[Category: | + | [[Category: Beta-propeller fold]] |
| - | [[Category: | + | [[Category: Cd26]] |
| - | [[Category: | + | [[Category: Dipetidyl peptidase iv]] |
| - | [[Category: | + | [[Category: Dppiv]] |
| - | [[Category: | + | [[Category: Protein-protein complex]] |
| - | [[Category: | + | [[Category: Serine protease]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:01:24 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:01, 3 May 2008
CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE
Overview
Dipeptidyl-peptidase IV (DPPIV or CD26) is a homodimeric type II membrane glycoprotein in which the two monomers are subdivided into a beta-propeller domain and an alpha/beta-hydrolase domain. As dipeptidase, DPPIV modulates the activity of various biologically important peptides and, in addition, DPPIV acts as a receptor for adenosine deaminase (ADA), thereby mediating co-stimulatory signals in T-lymphocytes. The 3.0-A resolution crystal structure of the complex formed between human DPPIV and bovine ADA presented here shows that each beta-propeller domain of the DPPIV dimer binds one ADA. At the binding interface, two hydrophobic loops protruding from the beta-propeller domain of DPPIV interact with two hydrophilic and heavily charged alpha-helices of ADA, giving rise to the highest percentage of charged residues involved in a protein-protein contact reported thus far. Additionally, four glycosides linked to Asn229 of DPPIV bind to ADA. In the crystal structure of porcine DPPIV, the observed tetramer formation was suggested to mediate epithelial and lymphocyte cell-cell adhesion. ADA binding to DPPIV could regulate this adhesion, as it would abolish tetramerization.
About this Structure
1W1I is a Protein complex structure of sequences from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface., Weihofen WA, Liu J, Reutter W, Saenger W, Fan H, J Biol Chem. 2004 Oct 8;279(41):43330-5. Epub 2004 Jun 22. PMID:15213224 Page seeded by OCA on Sat May 3 13:01:24 2008
Categories: Bos taurus | Dipeptidyl-peptidase IV | Homo sapiens | Protein complex | Fan, H. | Liu, J. | Reutter, W. | Saenger, W. | Weihofen, W A. | Ada | Adenosine deaminase | Alpha/beta-hydrolase fold | Aminopeptidase | Beta-propeller fold | Cd26 | Dipetidyl peptidase iv | Dppiv | Protein-protein complex | Serine protease
