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1w31

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[[Image:1w31.gif|left|200px]]
[[Image:1w31.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w31 |SIZE=350|CAPTION= <scene name='initialview01'>1w31</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1w31", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SHO:5-HYDROXYLAEVULINIC+ACID'>SHO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w31| PDB=1w31 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w31 OCA], [http://www.ebi.ac.uk/pdbsum/1w31 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w31 RCSB]</span>
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}}
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'''YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX'''
'''YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX'''
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[[Category: Warren, M J.]]
[[Category: Warren, M J.]]
[[Category: Wood, S P.]]
[[Category: Wood, S P.]]
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[[Category: aldolase]]
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[[Category: Aldolase]]
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[[Category: dehydratase]]
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[[Category: Dehydratase]]
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[[Category: heme biosynthesis]]
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[[Category: Heme biosynthesis]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: tetrapyrrole synthesis]]
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[[Category: Tetrapyrrole synthesis]]
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[[Category: tim barrel]]
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[[Category: Tim barrel]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:05:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:30:28 2008''
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Revision as of 10:05, 3 May 2008

Image:1w31.gif

Template:STRUCTURE 1w31

YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX


Overview

The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The structure shows that the inhibitor is bound by a Schiff-base link to one of the invariant active-site lysine residues (Lys263). The inhibitor appears to bind in two well defined conformations and the interactions made by it suggest that it is a very close analogue of the substrate 5-aminolaevulinic acid (ALA).

About this Structure

1W31 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of yeast 5-aminolaevulinic acid dehydratase complexed with the inhibitor 5-hydroxylaevulinic acid., Erskine PT, Coates L, Newbold R, Brindley AA, Stauffer F, Beaven GD, Gill R, Coker A, Wood SP, Warren MJ, Shoolingin-Jordan PM, Neier R, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1222-6. Epub 2005, Aug 16. PMID:16131755 Page seeded by OCA on Sat May 3 13:05:08 2008

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