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1w50

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[[Image:1w50.gif|left|200px]]
[[Image:1w50.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w50 |SIZE=350|CAPTION= <scene name='initialview01'>1w50</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1w50", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC2:Iod+Binding+Site+For+Chain+A'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w50| PDB=1w50 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w50 OCA], [http://www.ebi.ac.uk/pdbsum/1w50 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w50 RCSB]</span>
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}}
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'''APO STRUCTURE OF BACE (BETA SECRETASE)'''
'''APO STRUCTURE OF BACE (BETA SECRETASE)'''
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[[Category: Vuillard, L.]]
[[Category: Vuillard, L.]]
[[Category: Yon, J.]]
[[Category: Yon, J.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: alzheimer's disease]]
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[[Category: Alzheimer's disease]]
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[[Category: aspartic protease]]
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[[Category: Aspartic protease]]
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[[Category: aspartyl protease]]
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[[Category: Aspartyl protease]]
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[[Category: base]]
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[[Category: Base]]
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[[Category: beta-secretase]]
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[[Category: Beta-secretase]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: memapsin 2]]
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[[Category: Memapsin 2]]
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[[Category: signal]]
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[[Category: Signal]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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[[Category: zymogen]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:10:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:31:15 2008''
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Revision as of 10:10, 3 May 2008

Image:1w50.gif


PDB ID 1w50

Drag the structure with the mouse to rotate
1w50, resolution 1.75Å ()
Ligands:
Activity: Memapsin 2, with EC number 3.4.23.46
Related: 1fkn, 1m4h, 1py1, 1sgz, 1ujj, 1ujk, 1w51
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



APO STRUCTURE OF BACE (BETA SECRETASE)


Overview

Human BACE, also known as beta-secretase, shows promise as a potential therapeutic target for Alzheimer's disease. We determined the apo structure of BACE to 1.75 A, and a structure of a hydroxyethylamine inhibitor complex derived by soaking. These show significant active-site movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by structure-based drug design.

About this Structure

1W50 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669 Page seeded by OCA on Sat May 3 13:10:02 2008

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OCA

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