1w58

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[[Image:1w58.gif|left|200px]]
[[Image:1w58.gif|left|200px]]
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{{Structure
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|PDB= 1w58 |SIZE=350|CAPTION= <scene name='initialview01'>1w58</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1w58", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Chain+1'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_1w58| PDB=1w58 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w58 OCA], [http://www.ebi.ac.uk/pdbsum/1w58 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w58 RCSB]</span>
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'''FTSZ GMPCPP SOAK I213 (M. JANNASCHII)'''
'''FTSZ GMPCPP SOAK I213 (M. JANNASCHII)'''
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[[Category: Lowe, J.]]
[[Category: Lowe, J.]]
[[Category: Oliva, M A.]]
[[Category: Oliva, M A.]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: cell division protein]]
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[[Category: Cell division protein]]
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[[Category: cell-division protein]]
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[[Category: Cell-division protein]]
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[[Category: complete proteome]]
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[[Category: Complete proteome]]
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[[Category: ftsz]]
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[[Category: Ftsz]]
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[[Category: gtp-binding]]
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[[Category: Gtp-binding]]
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[[Category: multigene family]]
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[[Category: Multigene family]]
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[[Category: septation]]
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[[Category: Septation]]
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[[Category: tubulin]]
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[[Category: Tubulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:10:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:31:22 2008''
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Revision as of 10:10, 3 May 2008

Image:1w58.gif

Template:STRUCTURE 1w58

FTSZ GMPCPP SOAK I213 (M. JANNASCHII)


Overview

The prokaryotic tubulin homolog FtsZ polymerizes into a ring structure essential for bacterial cell division. We have used refolded FtsZ to crystallize a tubulin-like protofilament. The N- and C-terminal domains of two consecutive subunits in the filament assemble to form the GTPase site, with the C-terminal domain providing water-polarizing residues. A domain-swapped structure of FtsZ and biochemical data on purified N- and C-terminal domains show that they are independent. This leads to a model of how FtsZ and tubulin polymerization evolved by fusing two domains. In polymerized tubulin, the nucleotide-binding pocket is occluded, which leads to nucleotide exchange being the rate-limiting step and to dynamic instability. In our FtsZ filament structure the nucleotide is exchangeable, explaining why, in this filament, nucleotide hydrolysis is the rate-limiting step during FtsZ polymerization. Furthermore, crystal structures of FtsZ in different nucleotide states reveal notably few differences.

About this Structure

1W58 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Structural insights into FtsZ protofilament formation., Oliva MA, Cordell SC, Lowe J, Nat Struct Mol Biol. 2004 Dec;11(12):1243-50. Epub 2004 Nov 21. PMID:15558053 Page seeded by OCA on Sat May 3 13:10:47 2008

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