1w6s

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[[Image:1w6s.gif|left|200px]]
[[Image:1w6s.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1w6s |SIZE=350|CAPTION= <scene name='initialview01'>1w6s</scene>, resolution 1.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1w6s", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+C'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PQQ:PYRROLOQUINOLINE+QUINONE'>PQQ</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alcohol_dehydrogenase_(acceptor) Alcohol dehydrogenase (acceptor)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.99.8 1.1.99.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1w6s| PDB=1w6s | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w6s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w6s OCA], [http://www.ebi.ac.uk/pdbsum/1w6s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w6s RCSB]</span>
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}}
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'''THE HIGH RESOLUTION STRUCTURE OF METHANOL DEHYDROGENASE FROM METHYLOBACTERIUM EXTORQUENS'''
'''THE HIGH RESOLUTION STRUCTURE OF METHANOL DEHYDROGENASE FROM METHYLOBACTERIUM EXTORQUENS'''
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==Reference==
==Reference==
The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens., Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Jan;61(Pt 1):75-9. Epub 2004 Dec, 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15608378 15608378]
The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens., Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Jan;61(Pt 1):75-9. Epub 2004 Dec, 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15608378 15608378]
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[[Category: Alcohol dehydrogenase (acceptor)]]
 
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Thermomicrobium roseum]]
[[Category: Thermomicrobium roseum]]
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[[Category: Williams, P A.]]
[[Category: Williams, P A.]]
[[Category: Wood, S P.]]
[[Category: Wood, S P.]]
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[[Category: anisotropic,electron transfer]]
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[[Category: Anisotropic,electron transfer]]
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[[Category: calcium-binding]]
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[[Category: Calcium-binding]]
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[[Category: methanol utilization]]
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[[Category: Methanol utilization]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: pqq]]
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[[Category: Pqq]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:14:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:32:00 2008''
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Revision as of 10:14, 3 May 2008

Template:STRUCTURE 1w6s

THE HIGH RESOLUTION STRUCTURE OF METHANOL DEHYDROGENASE FROM METHYLOBACTERIUM EXTORQUENS


Overview

The crystal structure of methanol dehydrogenase (MDH) from Methylobacterium extorquens has been refined without stereochemical restraints at a resolution of 1.2 A. The high-resolution data have defined the conformation of the tricyclic pyrroloquinoline quinone (PQQ) cofactor ring as entirely planar. The detailed definition of the active-site geometry has shown many features that are similar to the quinohaemo-protein alcohol dehydrogenases from Comamonas testosteroni and Pseudomonas putida, both of which possess MDH-like and cytochrome c-like domains. Conserved features between the two types of PQQ-containing enzyme suggest a common pathway for electron transfer between MDH and its physiological electron acceptor cytochrome cL. A pathway for proton transfer from the active site to the bulk solvent is also suggested.

About this Structure

1W6S is a Protein complex structure of sequences from Thermomicrobium roseum. Full crystallographic information is available from OCA.

Reference

The atomic resolution structure of methanol dehydrogenase from Methylobacterium extorquens., Williams PA, Coates L, Mohammed F, Gill R, Erskine PT, Coker A, Wood SP, Anthony C, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Jan;61(Pt 1):75-9. Epub 2004 Dec, 17. PMID:15608378 Page seeded by OCA on Sat May 3 13:14:03 2008

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