This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1w9b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1w9b.gif|left|200px]]
[[Image:1w9b.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1w9b |SIZE=350|CAPTION= <scene name='initialview01'>1w9b</scene>, resolution 1.7&Aring;
+
The line below this paragraph, containing "STRUCTURE_1w9b", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+M'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CGT:CARBA-GLUCOTROPAEOLIN'>CGT</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioglucosidase Thioglucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.147 3.2.1.147] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1w9b| PDB=1w9b | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9b OCA], [http://www.ebi.ac.uk/pdbsum/1w9b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w9b RCSB]</span>
+
-
}}
+
'''S. ALBA MYROSINASE IN COMPLEX WITH CARBA-GLUCOTROPAEOLIN'''
'''S. ALBA MYROSINASE IN COMPLEX WITH CARBA-GLUCOTROPAEOLIN'''
Line 34: Line 31:
[[Category: Rollin, P.]]
[[Category: Rollin, P.]]
[[Category: Tatibouet, A.]]
[[Category: Tatibouet, A.]]
-
[[Category: glucotropaeolin]]
+
[[Category: Glucotropaeolin]]
-
[[Category: glusosinolate]]
+
[[Category: Glusosinolate]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: myrosinase]]
+
[[Category: Myrosinase]]
-
[[Category: thio-glucoside]]
+
[[Category: Thio-glucoside]]
-
[[Category: thioglucosidase]]
+
[[Category: Thioglucosidase]]
-
[[Category: thioglycosidase]]
+
[[Category: Thioglycosidase]]
-
[[Category: thiohydroximate]]
+
[[Category: Thiohydroximate]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:20:12 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:33:00 2008''
+

Revision as of 10:20, 3 May 2008

Image:1w9b.gif

Template:STRUCTURE 1w9b

S. ALBA MYROSINASE IN COMPLEX WITH CARBA-GLUCOTROPAEOLIN


Overview

Myrosinase, a thioglucoside glucohydrolase, is the only enzyme able to hydrolyse glucosinolates, a unique family of molecules bearing an anomeric O-sulfated thiohydroximate function. Non-hydrolysable myrosinase inhibitors have been devised and studied for their biological interaction. Diverse modifications of the O-sulfate moiety did not result in a significant inhibitory effect, whereas replacing the D-glucopyrano residue by its carba-analogue allowed inhibition to take place. X-Ray experiments carried out after soaking allowed for the first time inclusion of a non-hydrolysable inhibitor inside the enzymatic pocket. Structural tuning of the aglycon part in its pocket is being used as a guide for the development of simplified and more potent inhibitors.

About this Structure

1W9B is a Single protein structure of sequence from Sinapis alba. Full crystallographic information is available from OCA.

Reference

The glucosinolate-myrosinase system. New insights into enzyme-substrate interactions by use of simplified inhibitors., Bourderioux A, Lefoix M, Gueyrard D, Tatibouet A, Cottaz S, Arzt S, Burmeister WP, Rollin P, Org Biomol Chem. 2005 May 21;3(10):1872-9. Epub 2005 Apr 14. PMID:15889170 Page seeded by OCA on Sat May 3 13:20:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1w9b"
Personal tools