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5dlm

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Revision as of 08:09, 8 April 2020

Complex of Influenza M2e and Antibody

Structural highlights

5dlm is a 6 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[M2_I45A0] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).

Publication Abstract from PubMed

We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal beta-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.,Cho KJ, Schepens B, Moonens K, Deng L, Fiers W, Remaut H, Saelens X J Virol. 2015 Oct 14;90(1):611-5. doi: 10.1128/JVI.02105-15. PMID:26468526^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cho KJ, Schepens B, Moonens K, Deng L, Fiers W, Remaut H, Saelens X. Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody. J Virol. 2015 Oct 14;90(1):611-5. doi: 10.1128/JVI.02105-15. PMID:26468526 doi:http://dx.doi.org/10.1128/JVI.02105-15

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5dlm"

@@ Line 1: / Line 1: @@
 ==Complex of Influenza M2e and Antibody==
-<StructureSection load='5dlm' size='340' side='right' caption='[[5dlm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='5dlm' size='340' side='right'caption='[[5dlm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5dlm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DLM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DLM FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5dlm]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DLM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DLM FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dlm OCA], [http://pdbe.org/5dlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dlm RCSB], [http://www.ebi.ac.uk/pdbsum/5dlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dlm ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dlm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dlm OCA], [http://pdbe.org/5dlm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dlm RCSB], [http://www.ebi.ac.uk/pdbsum/5dlm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dlm ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 20: / Line 20: @@
 ==See Also==
-*[[3D structures of monoclonal antibody|3D structures of monoclonal antibody]]
+*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
 [[Category: Cho, K J]]

5dlm

From Proteopedia

Revision as of 08:09, 8 April 2020

Complex of Influenza M2e and Antibody

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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