1wa6

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[[Image:1wa6.jpg|left|200px]]
[[Image:1wa6.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1wa6 |SIZE=350|CAPTION= <scene name='initialview01'>1wa6</scene>, resolution 2.55&Aring;
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The line below this paragraph, containing "STRUCTURE_1wa6", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+X'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminocyclopropanecarboxylate_oxidase Aminocyclopropanecarboxylate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.17.4 1.14.17.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1wa6| PDB=1wa6 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wa6 OCA], [http://www.ebi.ac.uk/pdbsum/1wa6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wa6 RCSB]</span>
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}}
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'''THE STRUCTURE OF ACC OXIDASE'''
'''THE STRUCTURE OF ACC OXIDASE'''
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[[Category: Zhang, Z.]]
[[Category: Zhang, Z.]]
[[Category: 2og oxygenase]]
[[Category: 2og oxygenase]]
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[[Category: acc oxidase]]
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[[Category: Acc oxidase]]
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[[Category: acco]]
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[[Category: Acco]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:22:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:33:26 2008''
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Revision as of 10:22, 3 May 2008

Image:1wa6.jpg

Template:STRUCTURE 1wa6

THE STRUCTURE OF ACC OXIDASE


Overview

The final step in the biosynthesis of the plant signaling molecule ethylene is catalyzed by 1-aminocyclopropane-1-carboxylic acid oxidase (ACCO). ACCO requires bicarbonate as an activator and catalyzes the oxidation of ACC to give ethylene, CO2, and HCN. We report crystal structures of ACCO in apo-form (2.1 A resolution) and complexed with Fe(II) (2.55 A) or Co(II) (2.4 A). The active site contains a single Fe(II) ligated by three residues (His177, Asp179, and His234), and it is relatively open compared to those of the 2-oxoglutarate oxygenases. The side chains of Arg175 and Arg244, proposed to be involved in binding bicarbonate, project away from the active site, but conformational changes may allow either or both to enter the active site. The structures will form a basis for future mechanistic and inhibition studies.

About this Structure

1WA6 is a Single protein structure of sequence from Petunia x hybrida. Full crystallographic information is available from OCA.

Reference

Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme., Zhang Z, Ren JS, Clifton IJ, Schofield CJ, Chem Biol. 2004 Oct;11(10):1383-94. PMID:15489165 Page seeded by OCA on Sat May 3 13:22:23 2008

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