1waf

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[[Image:1waf.gif|left|200px]]
[[Image:1waf.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1waf |SIZE=350|CAPTION= <scene name='initialview01'>1waf</scene>, resolution 3.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1waf", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GMP:GUANOSINE'>GMP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12353 Enterobacteria phage RB69])
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-->
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|DOMAIN=
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{{STRUCTURE_1waf| PDB=1waf | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1waf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1waf OCA], [http://www.ebi.ac.uk/pdbsum/1waf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1waf RCSB]</span>
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}}
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'''DNA POLYMERASE FROM BACTERIOPHAGE RB69'''
'''DNA POLYMERASE FROM BACTERIOPHAGE RB69'''
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[[Category: Wang, C C.]]
[[Category: Wang, C C.]]
[[Category: Wang, J.]]
[[Category: Wang, J.]]
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[[Category: nucleotidyltransferase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: rb69 dna polymerase (gp43)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:23:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:33:30 2008''
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Revision as of 10:23, 3 May 2008

Image:1waf.gif

Template:STRUCTURE 1waf

DNA POLYMERASE FROM BACTERIOPHAGE RB69


Overview

The 2.8 A resolution crystal structure of the bacteriophage RB69 gp43, a member of the eukaryotic pol alpha family of replicative DNA polymerases, shares some similarities with other polymerases but shows many differences. Although its palm domain has the same topology as other polymerases, except rat DNA polymerase beta, one of the three carboxylates required for nucleotidyl transfer is located on a different beta strand. The structures of the fingers and thumb domains are unrelated to all other known polymerase structures. The editing 3'-5' exonuclease domain of gp43 is homologous to that of E. coli DNA polymerase I but lies on the opposite side of the polymerase active site. An extended structure-based alignment of eukaryotic DNA polymerase sequences provides structural insights that should be applicable to most eukaryotic DNA polymerases.

About this Structure

1WAF is a Single protein structure of sequence from Enterobacteria phage rb69. Full crystallographic information is available from OCA.

Reference

Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69., Wang J, Sattar AK, Wang CC, Karam JD, Konigsberg WH, Steitz TA, Cell. 1997 Jun 27;89(7):1087-99. PMID:9215631 Page seeded by OCA on Sat May 3 13:23:08 2008

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