1wcy

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[[Image:1wcy.gif|left|200px]]
[[Image:1wcy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1wcy |SIZE=350|CAPTION= <scene name='initialview01'>1wcy</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1wcy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1wcy| PDB=1wcy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wcy OCA], [http://www.ebi.ac.uk/pdbsum/1wcy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wcy RCSB]</span>
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}}
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'''Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A'''
'''Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A'''
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[[Category: Sugiyama, S.]]
[[Category: Sugiyama, S.]]
[[Category: Yamamoto, A.]]
[[Category: Yamamoto, A.]]
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[[Category: beta-propeller structure]]
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[[Category: Beta-propeller structure]]
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[[Category: cd26]]
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[[Category: Cd26]]
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[[Category: dipeptidyl peptidase iv]]
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[[Category: Dipeptidyl peptidase iv]]
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[[Category: diprotin some]]
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[[Category: Diprotin some]]
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[[Category: prolyl oligopeptidase]]
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[[Category: Prolyl oligopeptidase]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:29:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:34:36 2008''
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Revision as of 10:29, 3 May 2008

Image:1wcy.gif

Template:STRUCTURE 1wcy

Crystal Structure Of Human Dipeptidyl Peptidase IV (DPPIV) Complex With Diprotin A


Overview

Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, it seems important to develop selective inhibitors for human DPPIV (hDPPIV) that are able to control the biological function of hDPPIV. In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.

About this Structure

1WCY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A., Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R, Biol Chem. 2004 Jun;385(6):561-4. PMID:15255191 Page seeded by OCA on Sat May 3 13:29:08 2008

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