This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Plasmid segregation protein ParM

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
<StructureSection load='4a61' size='400' side='right' caption='plasmid segregation protein ParM complex with AMPPNP (stick model) and Mg+2 ion (green) (PDB code [[4a61]])' scene=''>
+
<StructureSection load='4a61' size='400' side='right' caption='plasmid segregation protein ParM complex with AMPPNP (stick model) and Mg+2 ion (green) (PDB code [[4a61]])' scene='' pspeed='8'>
== Function ==
== Function ==
'''Plasmid segregation protein''' (ParM) is required for plasmid partition and accurate segregation of low-copy-number plasmid R1<ref>PMID:20844556</ref>.
'''Plasmid segregation protein''' (ParM) is required for plasmid partition and accurate segregation of low-copy-number plasmid R1<ref>PMID:20844556</ref>.
== Structural highlights ==
== Structural highlights ==
-
ParM polymerizes into double helical protofilaments with repeats similar to F-actin.
+
ParM polymerizes into double helical protofilaments with repeats similar to F-actin. <scene name='71/715423/Cv/2'>AMPPNP binding site</scene>.
 +
*<scene name='71/715423/Cv/3'>Mg coordination site</scene>. Water molecules shown as red spheres.

Revision as of 11:26, 3 September 2017

plasmid segregation protein ParM complex with AMPPNP (stick model) and Mg+2 ion (green) (PDB code 4a61)

Drag the structure with the mouse to rotate

3D structures of plasmid segregation protein ParM

Updated on 03-September-2017

1mwk – ParM – Escherichias coli
1mwm – ParM + ADP
2zgy – ParM + GDP
2zgz – ParM + GMPPNP
4a61 – ParM + AMPPNP
5aey – ParM + AMPPNP - CryoEM
4a62 – ParM + ParR C terminus
2qu4, 2ghc, 3iku, 3iky, 4a6j, 5ai7 – ParM – CryoEM

References

  1. ↑ Salje J, Gayathri P, Lowe J. The ParMRC system: molecular mechanisms of plasmid segregation by actin-like filaments. Nat Rev Microbiol. 2010 Oct;8(10):683-92. doi: 10.1038/nrmicro2425. PMID:20844556 doi:http://dx.doi.org/10.1038/nrmicro2425

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Plasmid_segregation_protein_ParM"
Personal tools