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5oag
From Proteopedia
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| - | | + | #REDIRECT [[6f6p]] This PDB entry is obsolete and replaced by 6f6p |
| - | ==Crystal structure of tetrameric human Rabin8 GEF domain==
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| - | <StructureSection load='5oag' size='340' side='right' caption='[[5oag]], [[Resolution|resolution]] 2.48Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5oag]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OAG FirstGlance]. <br>
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| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oag OCA], [http://pdbe.org/5oag PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oag RCSB], [http://www.ebi.ac.uk/pdbsum/5oag PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oag ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/RAB3I_HUMAN RAB3I_HUMAN]] Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis.<ref>PMID:12221131</ref> <ref>PMID:20937701</ref> <ref>PMID:20890297</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Lorentzen, E]]
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| - | [[Category: Vetter, M]]
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| - | [[Category: Gef]]
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| - | [[Category: Guanine nucleotide exchange factor]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Rab3i]]
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| - | [[Category: Rabin8]]
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| - | [[Category: Tetramer]]
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Current revision
- REDIRECT 6f6p This PDB entry is obsolete and replaced by 6f6p
