This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Plectin
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '> | <Structure load='1sh6' size='400' caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '> | ||
== Function == | == Function == | ||
| - | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues | + | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues 300-1372) and N-terminal arm, which varies among isoforms. |
For more details see [[Group:MUZIC:Plectin]]. | For more details see [[Group:MUZIC:Plectin]]. | ||
| Line 15: | Line 15: | ||
[[1mb8]], [[4q59]] – hPCN actin-binding domain – human<br /> | [[1mb8]], [[4q59]] – hPCN actin-binding domain – human<br /> | ||
[[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse<br /> | [[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse<br /> | ||
| - | + | [[3pe0]] - hPCN plakin domain residues 747-918<br /> | |
| - | [[2odu]], [[2odv]] – hPCN plakin domain (mutant)<br /> | + | [[2odu]], [[2odv]] – hPCN plakin domain residues 300-530 (mutant)<br /> |
| + | [[3pdy]] – hPCN plakin domain repeats 3-4<br /> | ||
| + | [[5j1g]] – hPCN plakin domain repeats 7-8<br /> | ||
| + | [[5j1f]], [[5j1h]] – hPCN plakin domain repeats 5-6<br /> | ||
| + | [[5j1i]] – hPCN plakin domain repeats 7-9<br /> | ||
[[4gdo]] – hPCN rod domain<br /> | [[4gdo]] – hPCN rod domain<br /> | ||
[[3f7p]], [[4q58]] - hPCN actin-binding domain + integrin β4 residues 1126-1370<br /> | [[3f7p]], [[4q58]] - hPCN actin-binding domain + integrin β4 residues 1126-1370<br /> | ||
[[4q57]] - hPCN actin-binding domain + calmodulin N terminal<br /> | [[4q57]] - hPCN actin-binding domain + calmodulin N terminal<br /> | ||
| + | [[2n03]] – hPCN C-terminal repeat domain 6 - NMR<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:34, 11 September 2017
| |||||||||||
