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1wq6

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[[Image:1wq6.gif|left|200px]]
[[Image:1wq6.gif|left|200px]]
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{{Structure
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|PDB= 1wq6 |SIZE=350|CAPTION= <scene name='initialview01'>1wq6</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1wq6", creates the "Structure Box" on the page.
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|GENE= AML1/ETO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1wq6| PDB=1wq6 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wq6 OCA], [http://www.ebi.ac.uk/pdbsum/1wq6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wq6 RCSB]</span>
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'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''
'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''
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[[Category: Minor, W.]]
[[Category: Minor, W.]]
[[Category: Speck, N A.]]
[[Category: Speck, N A.]]
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[[Category: aml1-eto]]
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[[Category: Aml1-eto]]
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[[Category: eto]]
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[[Category: Eto]]
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[[Category: nhr2]]
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[[Category: Nhr2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:00:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:39:36 2008''
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Revision as of 11:00, 3 May 2008

Image:1wq6.gif

Template:STRUCTURE 1wq6

The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity


Overview

AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.

About this Structure

1WQ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:16616331 Page seeded by OCA on Sat May 3 14:00:13 2008

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