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1wqs

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[[Image:1wqs.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wqs OCA], [http://www.ebi.ac.uk/pdbsum/1wqs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wqs RCSB]</span>
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'''Crystal structure of Norovirus 3C-like protease'''
'''Crystal structure of Norovirus 3C-like protease'''
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[[Category: Tanaka, N.]]
[[Category: Tanaka, N.]]
[[Category: 3c-like protease]]
[[Category: 3c-like protease]]
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[[Category: chymotrypsin like protease]]
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[[Category: Chymotrypsin like protease]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: norovirus]]
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[[Category: Norovirus]]
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[[Category: norwalk-like virus]]
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[[Category: Norwalk-like virus]]
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[[Category: oxyanion hole]]
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[[Category: Oxyanion hole]]
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Revision as of 11:01, 3 May 2008

Image:1wqs.gif

Template:STRUCTURE 1wqs

Crystal structure of Norovirus 3C-like protease


Overview

Norovirus 3C-like proteases are crucial to proteolytic processing of norovirus polyproteins. We determined the crystal structure of the 3C-like protease from Chiba virus, a norovirus, at 2.8-A resolution. An active site including Cys139 and His30 is present, as is a hydrogen bond network that stabilizes the active site conformation. In the oxyanion hole backbone, a structural difference was observed probably upon substrate binding. A peptide substrate/enzyme model shows that several interactions between the two components are critical for substrate binding and that the S1 and S2 sites appropriately accommodate the substrate P1 and P2 residues, respectively. Knowledge of the structure and a previous mutagenesis study allow us to correlate proteolysis and structure.

About this Structure

1WQS is a Single protein structure of sequence from Chiba virus. Full crystallographic information is available from OCA.

Reference

A norovirus protease structure provides insights into active and substrate binding site integrity., Nakamura K, Someya Y, Kumasaka T, Ueno G, Yamamoto M, Sato T, Takeda N, Miyamura T, Tanaka N, J Virol. 2005 Nov;79(21):13685-93. PMID:16227288 Page seeded by OCA on Sat May 3 14:01:33 2008

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