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Prolyl hydroxylase domain
From Proteopedia
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== 3D Structures of prolyl hydroxylase domain == | == 3D Structures of prolyl hydroxylase domain == | ||
| - | [[2y33]] – hPHD2 | + | [[2y33]] – hPHD2 + Zn + quinolin derivative – human<br /> |
| - | [[ | + | [[3ouh]], [[3oui]], [[5v18]] - hPHD2 + Fe + inhibitor<br /> |
| - | [[ | + | [[4kbz]] - hPHD2 (mutant) + Fe + inhibitor<br /> |
| - | [[3ouj]] - hPHD2 | + | [[5a3u]] - hPHD2 + Mn + inhibitor<br /> |
| - | [[3hqr]] - hPHD2 | + | [[4jzr]] - hPHD2 + Ni + inhibitor<br /> |
| - | [[ | + | [[3ouj]] - hPHD2 + Fe + 2OG<br /> |
| - | [[2hbt]], [[2hbu]] - hPHD2 | + | [[5l9r]] - hPHD2 (mutant) + Mn + 2OG<br /> |
| - | [[ | + | [[3hqr]], [[5l9b]] - hPHD2 (mutant) + Mn + HIF 1 α C terminal + 2OG<br /> |
| + | [[5l9v]], [[5la9]], [[5las]] - hPHD2 (mutant) + Mn + HIF NODD domain + 2OG<br /> | ||
| + | [[3hqu]] - hPHD2 + Fe + HIF 1 α C terminal + quinolin derivative<br /> | ||
| + | [[2hbt]], [[2hbu]], [[2g19]], [[2g1m]], [[2y34], [[4bqi]]], [[2y34]] - hPHD2 + Fe + quinolin derivative<br /> | ||
| + | [[4bqw]], [[4bqx]], [[4bqy]] - hPHD2 + Mn + quinolin derivative<br /> | ||
| + | [[5lat]], [[5lb6]], [[5lbb]], [[5lbc]], [[5lbe]], [[5lbf]], [[4uwd]] - hPHD2 (mutant) + Mn + quinolin derivative<br /> | ||
[[4h6j]] – hPHD Pasb domain (mutant) + aryl hydrocarbon nuclear translocator (mutant)<br /> | [[4h6j]] – hPHD Pasb domain (mutant) + aryl hydrocarbon nuclear translocator (mutant)<br /> | ||
| + | [[5v1b]] - hPHD1 + Fe + inhibitor<br /> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 19:42, 19 September 2017
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3D Structures of prolyl hydroxylase domain
2y33 – hPHD2 + Zn + quinolin derivative – human
3ouh, 3oui, 5v18 - hPHD2 + Fe + inhibitor
4kbz - hPHD2 (mutant) + Fe + inhibitor
5a3u - hPHD2 + Mn + inhibitor
4jzr - hPHD2 + Ni + inhibitor
3ouj - hPHD2 + Fe + 2OG
5l9r - hPHD2 (mutant) + Mn + 2OG
3hqr, 5l9b - hPHD2 (mutant) + Mn + HIF 1 α C terminal + 2OG
5l9v, 5la9, 5las - hPHD2 (mutant) + Mn + HIF NODD domain + 2OG
3hqu - hPHD2 + Fe + HIF 1 α C terminal + quinolin derivative
2hbt, 2hbu, 2g19, 2g1m, [[2y34], 4bqi], 2y34 - hPHD2 + Fe + quinolin derivative
4bqw, 4bqx, 4bqy - hPHD2 + Mn + quinolin derivative
5lat, 5lb6, 5lbb, 5lbc, 5lbe, 5lbf, 4uwd - hPHD2 (mutant) + Mn + quinolin derivative
4h6j – hPHD Pasb domain (mutant) + aryl hydrocarbon nuclear translocator (mutant)
5v1b - hPHD1 + Fe + inhibitor
References
- ↑ Stolze IP, Mole DR, Ratcliffe PJ. Regulation of HIF: prolyl hydroxylases. Novartis Found Symp. 2006;272:15-25; discussion 25-36. PMID:16686427
- ↑ Rosen M D, Venkatesan H, Peltier H M, Bembenek S D, Kanelakis K C, Zhao L X, Leonard B E, Hocutt F M, Wu X, Palomino H L, Brondtetter T I, Haugh P V, Cagnon L, Yan W, Liotta L A, Young A, Mirzadegan T, Shankley N P, Barrett T D, Rabinowitz M H. Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues. ACS Medicinal Chemical Letters. 2010 Oct 5.
Created with the participation of Andrew Winslow.
