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Proteasome

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**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
-
**[[3gpt]], [[3gpw]], [[1g0u]] – y20S core - yeast<br />
+
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />
-
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]] - y20S core (mutant)<br />
+
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]] - y20S core (mutant)<br />
**[[4r3o]] – h20S – human<br />
**[[4r3o]] – h20S – human<br />
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
Line 37: Line 37:
**[[1z7q]], [[1fnt]] – y20S core+PA26<br />
**[[1z7q]], [[1fnt]] – y20S core+PA26<br />
**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />
**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />
 +
**[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br />
*Proteasome 20S+inhibitor
*Proteasome 20S+inhibitor
-
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]] – y20S core+inhibitor<br />
+
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]] – y20S core+inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]] – y20S (mutant) + inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]] – y20S (mutant) + inhibitor<br />
**[[3tdd]], [[4j70]] - y20S core + belactosin<br />
**[[3tdd]], [[4j70]] - y20S core + belactosin<br />
Line 51: Line 52:
**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]] – y20S (mutant) + lymphoma drug<br />
**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]] – y20S (mutant) + lymphoma drug<br />
**[[4r67]] – h20S + cancer drug<br />
**[[4r67]] – h20S + cancer drug<br />
 +
**[[4x6z]] - y20S + modulator<br />
**[[3unb]], [[3unf]] – m20S + inhibitor
**[[3unb]], [[3unf]] – m20S + inhibitor
Line 63: Line 65:
*Proteasome partial 26S particle
*Proteasome partial 26S particle
 +
**[[5l4k]] - hPRTS lid - CryoEM<br />
**[[1p9c]] – hPRTS subunit 4 C-terminal<br />
**[[1p9c]] – hPRTS subunit 4 C-terminal<br />
**[[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br />
**[[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br />
Line 94: Line 97:
*Proteasome 26S particle
*Proteasome 26S particle
-
**[[3j47]], [[4cr2]], [[4cr3]], [[4cr4]] – yPRTS – Cryo EM<br />
+
**[[3j47]], [[4cr2]], [[4cr3]], [[4cr4]], [[5wvi]], [[5mpc]] – yPRTS – Cryo EM<br />
 +
**[[5wvk]] - yPRTS + ADP - Cryo EM<br />
 +
**[[5mp9]], [[5mpa]], [[5mpd]], [[5mpe]] - yPRTS + ATP - Cryo EM<br />
**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br />
**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br />
 +
**[[5a5b]] - yPRTS + UBP6 - Cryo EM<br />
 +
**[[5l4g]], [[5gjr]], [[5ln3]] - hPRTS - Cryo EM<br />
 +
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 21:40, 19 September 2017

Yeast proteasome 20S core complex with salinosporamide derivative, 3gpt

Drag the structure with the mouse to rotate

3D Structures of Proteasome

Updated on 19-September-2017

References

  1. ↑ Saeki Y, Tanaka K. Assembly and function of the proteasome. Methods Mol Biol. 2012;832:315-37. doi: 10.1007/978-1-61779-474-2_22. PMID:22350895 doi:http://dx.doi.org/10.1007/978-1-61779-474-2_22
  2. ↑ Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem. 1996;65:801-47. PMID:8811196 doi:http://dx.doi.org/10.1146/annurev.bi.65.070196.004101

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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