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Proteasome

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**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />
-
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]] - y20S core (mutant)<br />
+
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[5fg7]], [[5fg9]], [[5fga]] - y20S core (mutant)<br />
-
**[[4r3o]] – h20S – human<br />
+
**[[4r3o]], [[5le5]], [[5lex]] – h20S – human<br />
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
-
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]] – Ta20S core - ''Themoplasma acidophilum''<br />
+
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />
**[[2h6j]], [[1q5r]] – Re20S core (mutant) – ''Rhodococcus erythropolis''<br />
Line 34: Line 34:
*Proteasome 20S+activator protein
*Proteasome 20S+activator protein
-
**[[4v7o]] – y20S core+ Blm10 <br />
+
**[[4v7o]], [[5nif]] – y20S core+ Blm10 <br />
**[[1z7q]], [[1fnt]] – y20S core+PA26<br />
**[[1z7q]], [[1fnt]] – y20S core+PA26<br />
**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />
**[[3ipm]], [[3jrm]], [[3jse]], [[3jtl]], [[1ya7]], [[1yar]], [[1yau]] - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U <br />
Line 41: Line 41:
*Proteasome 20S+inhibitor
*Proteasome 20S+inhibitor
-
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]] – y20S core+inhibitor<br />
+
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[4z1l]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]] – y20S core+inhibitor<br />
-
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]] – y20S (mutant) + inhibitor<br />
+
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5bxn]], [[5cgg]], [[5cgh]], [[5cgi]], [[5cz5]], [[5d05]], [[5d0s]], [[5d0t]], [[5d0v]], [[5d0x]], [[5d0z]], [[5fgh]], [[4r00]] – y20S (mutant) + inhibitor<br />
**[[3tdd]], [[4j70]] - y20S core + belactosin<br />
**[[3tdd]], [[4j70]] - y20S core + belactosin<br />
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br />
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br />
**[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br />
**[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br />
 +
**[[5cz6]], [[5cz7]] - y20S (mutant) + peptide inhibitor<br />
**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]] – Mt20S core+inhibitor<br />
**[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]] – Mt20S core+inhibitor<br />
**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br />
**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br />
-
**[[2zcy]] – y20S+syringolin<br />
 
**[[4qvl]], [[4qw4]] – y20S + lymphoma drug<br />
**[[4qvl]], [[4qw4]] – y20S + lymphoma drug<br />
**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]] – y20S (mutant) + lymphoma drug<br />
**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]] – y20S (mutant) + lymphoma drug<br />
 +
**[[5cz8]], [[5cz9]], [[5fgd]], [[5fge]], [[5fgf]], [[5fgg]], [[5fgi]], [[5fhs]] - y20S (mutant) + cancer drug<br />
**[[4r67]] – h20S + cancer drug<br />
**[[4r67]] – h20S + cancer drug<br />
**[[4x6z]] - y20S + modulator<br />
**[[4x6z]] - y20S + modulator<br />
-
**[[3unb]], [[3unf]] – m20S + inhibitor
+
**[[5gjq]] - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin<br />
 +
**[[5l5a]] - y20S + h20S beta5i<br />
 +
**[[5ltt]] - y20S + h20S beta5i + inhibitor<br />
 +
**[[5l5b]], [[5l5r]] - y20S + h20S beta5i + h20S beta6<br />
 +
**[[5l5w]] - y20S + h20S beta5c + h20S beta6<br />
 +
**[[5l5x]], [[5l60]], [[5l61]] - y20S + h20S beta5c + h20S beta6 + inhibitor<br />
 +
**[[5l5y]], [[5l5z]] - y20S + h20S beta5c + h20S beta6 + cancer drug<br />
 +
**[[5l5d]], [[5l5h]], [[5l5q]], [[5l5i]], [[5l5j]], [[5l5o]], [[5l5p]], [[5l5s]], [[5l5t]], [[5l5u]], [[5l5v]], [[5l62]], [[5l63]], [[5l64]], [[5l68]], [[5l69]], [[5l6a]], [[5l6c]], [[5m2b]] - y20S + h20S beta5i + h20S beta6 + inhibitor<br />
 +
**[[5l5e]], [[5l5f]] - y20S + h20S beta5i + h20S beta6 + cancer drug<br />
 +
**[[5l65]], [[5l66]] - y20S + m20S beta5i + m20S beta6 + cancer drug<br />
 +
**[[5l67]], [[5l6b]] - y20S + m20S beta5i + m20S beta6 + inhibitor<br />
 +
**[[3unb]], [[3unf]] – m20S + inhibitor<br />
 +
**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]] - h20S + inhibitor<br />
 +
**[[5a0q]] - h20S + substrate analog<br />
 +
**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br />
 +
**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br />
* Proteasome partial 20S particle
* Proteasome partial 20S particle
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**[[5l4k]] - hPRTS lid - CryoEM<br />
**[[5l4k]] - hPRTS lid - CryoEM<br />
 +
**[[5dsv]] - hPRTS subunit a type-3<br />
**[[1p9c]] – hPRTS subunit 4 C-terminal<br />
**[[1p9c]] – hPRTS subunit 4 C-terminal<br />
**[[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br />
**[[1p9d]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain<br />
Line 100: Line 117:
**[[5wvk]] - yPRTS + ADP - Cryo EM<br />
**[[5wvk]] - yPRTS + ADP - Cryo EM<br />
**[[5mp9]], [[5mpa]], [[5mpd]], [[5mpe]] - yPRTS + ATP - Cryo EM<br />
**[[5mp9]], [[5mpa]], [[5mpd]], [[5mpe]] - yPRTS + ATP - Cryo EM<br />
 +
**[[5mpb]] - yPRTS + AMPPNP - Cryo EM<br />
**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br />
**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br />
**[[5a5b]] - yPRTS + UBP6 - Cryo EM<br />
**[[5a5b]] - yPRTS + UBP6 - Cryo EM<br />
-
**[[5l4g]], [[5gjr]], [[5ln3]] - hPRTS - Cryo EM<br />
+
**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]] - hPRTS - Cryo EM<br />
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />
}}
}}

Revision as of 20:11, 20 September 2017

Yeast proteasome 20S core complex with salinosporamide derivative, 3gpt

Drag the structure with the mouse to rotate

3D Structures of Proteasome

Updated on 20-September-2017

References

  1. ↑ Saeki Y, Tanaka K. Assembly and function of the proteasome. Methods Mol Biol. 2012;832:315-37. doi: 10.1007/978-1-61779-474-2_22. PMID:22350895 doi:http://dx.doi.org/10.1007/978-1-61779-474-2_22
  2. ↑ Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem. 1996;65:801-47. PMID:8811196 doi:http://dx.doi.org/10.1146/annurev.bi.65.070196.004101

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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