1wt6
From Proteopedia
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'''Coiled-Coil domain of DMPK''' | '''Coiled-Coil domain of DMPK''' | ||
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[[Category: Marino, M.]] | [[Category: Marino, M.]] | ||
[[Category: Mayans, O.]] | [[Category: Mayans, O.]] | ||
| - | [[Category: | + | [[Category: Coiled-coil]] |
| - | [[Category: | + | [[Category: Dmpk]] |
| - | [[Category: | + | [[Category: Kinase activation]] |
| - | [[Category: | + | [[Category: Molecular replacement]] |
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Revision as of 11:06, 3 May 2008
Coiled-Coil domain of DMPK
Overview
The coiled-coil domain of dystrophia myotonica protein kinase (DMPK) has been cloned, overexpressed, purified and crystallized. Two crystal forms have been obtained that belong to space groups P3 and P2(1)2(1)2(1) and diffract to 2.4 and 1.6 A resolution, respectively. Experimental phases were obtained by MAD from an SeMet derivative. The location of selenium sites used molecular-replacement phases obtained from search models lacking sequence similarity with the coiled-coil under study. Both crystal forms contain three polypeptide chains in the asymmetric unit.
About this Structure
1WT6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystallization and preliminary X-ray analysis of the coiled-coil domain of dystrophia myotonica kinase., Garcia P, Marino M, Mayans O, Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2336-9. Epub, 2004 Nov 26. PMID:15583383 Page seeded by OCA on Sat May 3 14:06:15 2008
