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1gwn
From Proteopedia
(Difference between revisions)
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<StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1gwn' size='340' side='right' caption='[[1gwn]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1gwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GWN FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rnd3, Arhe, Rhoe ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwn OCA], [http://pdbe.org/1gwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1gwn RCSB], [http://www.ebi.ac.uk/pdbsum/1gwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RND3_MOUSE RND3_MOUSE]] Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwn_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwn_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Garavini, H]] | [[Category: Garavini, H]] | ||
[[Category: Keep, N H]] | [[Category: Keep, N H]] | ||
| - | [[Category: | + | [[Category: McAlister, M S.B]] |
[[Category: Phelan, J P]] | [[Category: Phelan, J P]] | ||
[[Category: Ridley, A J]] | [[Category: Ridley, A J]] | ||
Revision as of 05:58, 20 June 2018
The crystal structure of the core domain of RhoE/Rnd3 - a constitutively activated small G protein
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