1wv4

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[[Image:1wv4.jpg|left|200px]]
[[Image:1wv4.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1wv4 |SIZE=350|CAPTION= <scene name='initialview01'>1wv4</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1wv4", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1wv4| PDB=1wv4 | SCENE= }}
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|RELATEDENTRY=[[1dnl|1DNL]], [[1jnw|1JNW]], [[1g79|1G79]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wv4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wv4 OCA], [http://www.ebi.ac.uk/pdbsum/1wv4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wv4 RCSB]</span>
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}}
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'''X-ray Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in tetragonal crystal form'''
'''X-ray Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in tetragonal crystal form'''
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[[Category: Safo, M K.]]
[[Category: Safo, M K.]]
[[Category: Schirch, V.]]
[[Category: Schirch, V.]]
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[[Category: fmn]]
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[[Category: Fmn]]
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[[Category: oxidase]]
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[[Category: Oxidase]]
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[[Category: plp]]
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[[Category: Plp]]
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[[Category: pyridoxal]]
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[[Category: Pyridoxal]]
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[[Category: pyridoxine 5'-phosphate]]
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[[Category: Pyridoxine 5'-phosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:10:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:41:24 2008''
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Revision as of 11:10, 3 May 2008

Image:1wv4.jpg

Template:STRUCTURE 1wv4

X-ray Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in tetragonal crystal form


Overview

Escherichia coli pyridoxine 5'-phosphate oxidase (ePNPOx) catalyzes the terminal step in the biosynthesis of pyridoxal 5'-phosphate (PLP) by the FMN oxidation of pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP), forming FMNH(2) and H(2)O(2). The crystal structure of ePNPOx is reported in a tetragonal unit cell at 2.6 A resolution. The three-dimensional fold of this structure is very similar to those of the E. coli and human enzymes that crystallized in trigonal and monoclinic unit cells. However, unlike the previous structures, the tetragonal structure shows major disorder in one of the two subunit domains that has opened up both the active site and a putative tunnel. Comparison of these structures gives an insight into the mechanistic pathway of PNPOx: from the resting enzyme with no substrate bound, to the initial binding of the substrate at the active site, to the catalytic stage and to the release of the catalytic product from the active site.

About this Structure

1WV4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme., Safo MK, Musayev FN, Schirch V, Acta Crystallogr D Biol Crystallogr. 2005 May;61(Pt 5):599-604. Epub 2005, Apr 20. PMID:15858270 Page seeded by OCA on Sat May 3 14:10:46 2008

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