Proto-oncogene serine/threonine-protein kinase
From Proteopedia
(Difference between revisions)
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**[[3a99]] – hPim1 + phosphoaminophosphonic acid adenylate <br /> | **[[3a99]] – hPim1 + phosphoaminophosphonic acid adenylate <br /> | ||
**[[2bzj]], [[2bzh]], [[2bzi]], [[2oi4]], [[3bwf]] – hPim1 (mutant) + organometallic ligand <br /> | **[[2bzj]], [[2bzh]], [[2bzi]], [[2oi4]], [[3bwf]] – hPim1 (mutant) + organometallic ligand <br /> | ||
| - | **[[1xws]], [[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[4dtk]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[4ll5]], [[4lm5]], [[3c4e]] – hPim1 + inhibitor <br /> | + | **[[1xws]], [[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[4dtk]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[4ll5]], [[4lm5]], [[3c4e]], [[4xhk]], [[4rpv]], [[5kgd]], [[5kge]], [[5kgg]], [[5kgi]], [[5kgk]], [[4xh6]], [[5dhj]], [[5dia]], [[5v82]], [[4ty1]], [[4wrs]], [[4wsy]], [[4wt6]], [[5dgz]], [[5dwr]], [[5eol]], [[5ipj]], [[5kcx]], [[5kzi]], [[5c1q]] – hPim1 + inhibitor <br /> |
**[[2j2i]] – hPim1 (mutant)+ inhibitor <br /> | **[[2j2i]] – hPim1 (mutant)+ inhibitor <br /> | ||
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**[[2bzk]] – hPim1 (mutant)+ AMPPNP + consensus peptide <br /> | **[[2bzk]] – hPim1 (mutant)+ AMPPNP + consensus peptide <br /> | ||
**[[2bil]], [[3cxw]], [[3cy2]], [[3cy3]], [[3jpv]], [[3qf9]] – hPim1 + inhibitor + consensus peptide<br /> | **[[2bil]], [[3cxw]], [[3cy2]], [[3cy3]], [[3jpv]], [[3qf9]] – hPim1 + inhibitor + consensus peptide<br /> | ||
| - | **[[3ma3]] – hPim1 + inhibitor + PSer + consensus peptide<br /> | + | **[[3ma3]], [[4jx7]] – hPim1 + inhibitor + PSer + consensus peptide<br /> |
*Pim1 containing phosphorylated Ser 261 | *Pim1 containing phosphorylated Ser 261 | ||
**[[1yhs]] – hPim1 + PSer + staurosporine <br /> | **[[1yhs]] – hPim1 + PSer + staurosporine <br /> | ||
| - | **[[1yi3]], [[2bik]], [[2obj]], [[3bgp]], [[3bgq]], [[3bgz]], [[3dcv]], [[3f2a]], [[2xix]], [[2xiy]], [[2xiz]], [[2xj0]], [[2xj1]], [[2xj2]], [[3t9i]], [[4a7c]] – hPim1 + PSer + inhibitor <br /> | + | **[[1yi3]], [[2bik]], [[2obj]], [[3bgp]], [[3bgq]], [[3bgz]], [[3dcv]], [[3f2a]], [[2xix]], [[2xiy]], [[2xiz]], [[2xj0]], [[2xj1]], [[2xj2]], [[3t9i]], [[4a7c]], [[4rbl]], [[4rc2]], [[4rc3]], [[4rc4]], [[5iis]] – hPim1 + PSer + inhibitor <br /> |
**[[1yi4]] – hPim1 + PSer + adenosine <br /> | **[[1yi4]] – hPim1 + PSer + adenosine <br /> | ||
Revision as of 19:16, 21 September 2017
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3D Structures of pim-1
Updated on 21-September-2017
References
- ↑ Bachmann M, Moroy T. The serine/threonine kinase Pim-1. Int J Biochem Cell Biol. 2005 Apr;37(4):726-30. PMID:15694833 doi:http://dx.doi.org/10.1016/j.biocel.2004.11.005
- ↑ Brault L, Menter T, Obermann EC, Knapp S, Thommen S, Schwaller J, Tzankov A. PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma. Br J Cancer. 2012 Jul 24;107(3):491-500. doi: 10.1038/bjc.2012.272. Epub 2012 Jun, 21. PMID:22722314 doi:http://dx.doi.org/10.1038/bjc.2012.272
- ↑ Weirauch U, Beckmann N, Thomas M, Grunweller A, Huber K, Bracher F, Hartmann RK, Aigner A. Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma. Neoplasia. 2013 Jul;15(7):783-94. PMID:23814490
- ↑ Huber K, Brault L, Fedorov O, Gasser C, Filippakopoulos P, Bullock AN, Fabbro D, Trappe J, Schwaller J, Knapp S, Bracher F. 7,8-Dichloro-1-oxo-beta-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes. J Med Chem. 2012 Jan 12;55(1):403-13. Epub 2012 Jan 3. PMID:22136433 doi:10.1021/jm201286z
