1wwl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1wwl.gif|left|200px]]
[[Image:1wwl.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1wwl |SIZE=350|CAPTION= <scene name='initialview01'>1wwl</scene>, resolution 2.50&Aring;
+
The line below this paragraph, containing "STRUCTURE_1wwl", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1wwl| PDB=1wwl | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wwl OCA], [http://www.ebi.ac.uk/pdbsum/1wwl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wwl RCSB]</span>
+
-
}}
+
'''Crystal structure of CD14'''
'''Crystal structure of CD14'''
Line 32: Line 29:
[[Category: Lee, J O.]]
[[Category: Lee, J O.]]
[[Category: Paik, S G.]]
[[Category: Paik, S G.]]
-
[[Category: cd14]]
+
[[Category: Cd14]]
-
[[Category: lp]]
+
[[Category: Lp]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:14:03 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:41:56 2008''
+

Revision as of 11:14, 3 May 2008

Image:1wwl.gif

Template:STRUCTURE 1wwl

Crystal structure of CD14


Overview

Lipopolysaccharide, the endotoxin of Gram-negative bacteria, induces extensive immune responses that can lead to fatal septic shock syndrome. The core receptors recognizing lipopolysaccharide are CD14, TLR4, and MD-2. CD14 binds to lipopolysaccharide and presents it to the TLR4/MD-2 complex, which initiates intracellular signaling. In addition to lipopolysaccharide, CD14 is capable of recognizing a few other microbial and cellular products. Here, we present the first crystal structure of CD14 to 2.5 angstroms resolution. A large hydrophobic pocket was found on the NH2-terminal side of the horseshoe-like structure. Previously identified regions involved in lipopolysaccharide binding map to the rim and bottom of the pocket indicating that the pocket is the main component of the lipopolysaccharide-binding site. Mutations that interfere with lipopolysaccharide signaling but not with lipopolysaccharide binding are also clustered in a separate area near the pocket. Ligand diversity of CD14 could be explained by the generous size of the pocket, the considerable flexibility of the rim of the pocket, and the multiplicity of grooves available for ligand binding.

About this Structure

1WWL is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of CD14 and its implications for lipopolysaccharide signaling., Kim JI, Lee CJ, Jin MS, Lee CH, Paik SG, Lee H, Lee JO, J Biol Chem. 2005 Mar 25;280(12):11347-51. Epub 2005 Jan 10. PMID:15644310 Page seeded by OCA on Sat May 3 14:14:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wwl"
Personal tools