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5do7

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Revision as of 08:59, 4 December 2019

Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8

Structural highlights

5do7 is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	ABCG5 (HUMAN), ABCG8 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[ABCG5_HUMAN] Sitosterolemia. The disease is caused by mutations affecting the gene represented in this entry. [ABCG8_HUMAN] Sitosterolemia. Disease susceptibility may be associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[ABCG5_HUMAN] Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. [ABCG8_HUMAN] Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.

Publication Abstract from PubMed

ATP binding cassette (ABC) transporters play critical roles in maintaining sterol balance in higher eukaryotes. The ABCG5/ABCG8 heterodimer (G5G8) mediates excretion of neutral sterols in liver and intestines. Mutations disrupting G5G8 cause sitosterolaemia, a disorder characterized by sterol accumulation and premature atherosclerosis. Here we use crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 A resolution, generating the first atomic model of an ABC sterol transporter. The structure reveals a new transmembrane fold that is present in a large and functionally diverse superfamily of ABC transporters. The transmembrane domains are coupled to the nucleotide-binding sites by networks of interactions that differ between the active and inactive ATPases, reflecting the catalytic asymmetry of the transporter. The G5G8 structure provides a mechanistic framework for understanding sterol transport and the disruptive effects of mutations causing sitosterolaemia.

Crystal structure of the human sterol transporter ABCG5/ABCG8.,Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z, Hobbs HH, Rosenbaum DM Nature. 2016 May 4;533(7604):561-4. doi: 10.1038/nature17666. PMID:27144356^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z, Hobbs HH, Rosenbaum DM. Crystal structure of the human sterol transporter ABCG5/ABCG8. Nature. 2016 May 4;533(7604):561-4. doi: 10.1038/nature17666. PMID:27144356 doi:http://dx.doi.org/10.1038/nature17666

1 Structural highlights
2 Disease
3 Function
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5do7"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8==
-<StructureSection load='5do7' size='340' side='right' caption='[[5do7]], [[Resolution|resolution]] 3.93&Aring;' scene=''>
+<StructureSection load='5do7' size='340' side='right'caption='[[5do7]], [[Resolution|resolution]] 3.93&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5do7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DO7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5do7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DO7 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5do7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do7 OCA], [http://pdbe.org/5do7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5do7 RCSB], [http://www.ebi.ac.uk/pdbsum/5do7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5do7 ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABCG5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ABCG8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5do7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do7 OCA], [http://pdbe.org/5do7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5do7 RCSB], [http://www.ebi.ac.uk/pdbsum/5do7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5do7 ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 23: / Line 24: @@
 __TOC__
 </StructureSection>
+[[Category: Human]]
+[[Category: Large Structures]]
 [[Category: Borek, D M]]
 [[Category: Cohen, J C]]

5do7

From Proteopedia

Revision as of 08:59, 4 December 2019

Crystal Structure of the Human Sterol Transporter ABCG5/ABCG8

Structural highlights

Disease

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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