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1wxz

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[[Image:1wxz.gif|left|200px]]
[[Image:1wxz.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1wxz |SIZE=350|CAPTION= <scene name='initialview01'>1wxz</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1wxz", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FRL:1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE'>FRL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosine_deaminase Adenosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.4 3.5.4.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1wxz| PDB=1wxz | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxz OCA], [http://www.ebi.ac.uk/pdbsum/1wxz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wxz RCSB]</span>
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}}
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'''Crystal structure of adenosine deaminase ligated with a potent inhibitor'''
'''Crystal structure of adenosine deaminase ligated with a potent inhibitor'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Kinoshita, T.]]
[[Category: Kinoshita, T.]]
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[[Category: beta barel]]
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[[Category: Beta barel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:17:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:42:30 2008''
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Revision as of 11:17, 3 May 2008

Image:1wxz.gif

Template:STRUCTURE 1wxz

Crystal structure of adenosine deaminase ligated with a potent inhibitor


Overview

From metabolic considerations and prediction of an inhibitor-induced conformational change, novel adenosine deaminase (ADA) inhibitors with improved activities and oral bioavailability have been developed on the basis of our originally designed non-nucleoside ADA inhibitors. They demonstrated in vivo efficacy in models of inflammation and lymphoma. Furthermore, X-ray crystal structure analysis has revealed a novel induced fit to ADA.

About this Structure

1WXZ is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism., Terasaka T, Tsuji K, Kato T, Nakanishi I, Kinoshita T, Kato Y, Kuno M, Inoue T, Tanaka K, Nakamura K, J Med Chem. 2005 Jul 28;48(15):4750-3. PMID:16033254 Page seeded by OCA on Sat May 3 14:17:25 2008

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OCA

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