5h5c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Mdm12 from K. lactis (1-239), uniformly Lys dimethyl modified, crystallized in FOS-MEA-10== | |
| - | + | <StructureSection load='5h5c' size='340' side='right' caption='[[5h5c]], [[Resolution|resolution]] 3.31Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5h5c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H5C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h55|5h55]], [[5h54|5h54]], [[5h5a|5h5a]]</td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h5c OCA], [http://pdbe.org/5h5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h5c RCSB], [http://www.ebi.ac.uk/pdbsum/5h5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h5c ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MDM12_KLULA MDM12_KLULA]] Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Endo, T]] | [[Category: Endo, T]] | ||
| + | [[Category: Kawano, S]] | ||
[[Category: Quinbara, S]] | [[Category: Quinbara, S]] | ||
| - | [[Category: | + | [[Category: Lipid binding protein]] |
Revision as of 07:46, 8 November 2017
Mdm12 from K. lactis (1-239), uniformly Lys dimethyl modified, crystallized in FOS-MEA-10
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