1x1l

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[[Image:1x1l.gif|left|200px]]
[[Image:1x1l.gif|left|200px]]
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{{Structure
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|PDB= 1x1l |SIZE=350|CAPTION= <scene name='initialview01'>1x1l</scene>
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The line below this paragraph, containing "STRUCTURE_1x1l", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1x1l| PDB=1x1l | SCENE= }}
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|RELATEDENTRY=[[1fjf|1FJF]], [[1ega|1EGA]], [[1wf3|1WF3]], [[1x18|1X18]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x1l OCA], [http://www.ebi.ac.uk/pdbsum/1x1l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x1l RCSB]</span>
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'''Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit.'''
'''Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit.'''
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[[Category: Barat, C.]]
[[Category: Barat, C.]]
[[Category: Sharma, M R.]]
[[Category: Sharma, M R.]]
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[[Category: interaction of era protein with the 3'minor domain of 16s rrna]]
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[[Category: Interaction of era protein with the 3'minor domain of 16s rrna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:24:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:43:39 2008''
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Revision as of 11:24, 3 May 2008

Image:1x1l.gif

Template:STRUCTURE 1x1l

Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit.


Overview

Era (E. coliRas-like protein) is a highly conserved and essential GTPase in bacteria. It binds to the 16S ribosomal RNA (rRNA) of the small (30S) ribosomal subunit, and its depletion leads to accumulation of an unprocessed precursor of the 16S rRNA. We have obtained a three-dimensional cryo-electron microscopic map of the Thermus thermophilus 30S-Era complex. Era binds in the cleft between the head and platform of the 30S subunit and locks the subunit in a conformation that is not favorable for association with the large (50S) ribosomal subunit. The RNA binding KH motif present within the C-terminal domain of Era interacts with the conserved nucleotides in the 3' region of the 16S rRNA. Furthermore, Era makes contact with several assembly elements of the 30S subunit. These observations suggest a direct involvement of Era in the assembly and maturation of the 30S subunit.

About this Structure

1X1L is a Single protein structure of sequence from Escherichia coli and Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Interaction of Era with the 30S ribosomal subunit implications for 30S subunit assembly., Sharma MR, Barat C, Wilson DN, Booth TM, Kawazoe M, Hori-Takemoto C, Shirouzu M, Yokoyama S, Fucini P, Agrawal RK, Mol Cell. 2005 Apr 29;18(3):319-29. PMID:15866174 Page seeded by OCA on Sat May 3 14:24:47 2008

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