5ogc

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m (Protected "5ogc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5ogc is ON HOLD
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==Molecular basis of human kinesin-8 function and inhibition==
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<StructureSection load='5ogc' size='340' side='right' caption='[[5ogc]], [[Resolution|resolution]] 4.80&Aring;' scene=''>
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Authors: Locke, J., Joseph, A.P., Topf, M., Moores, C.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ogc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ], [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OGC FirstGlance]. <br>
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Description: Molecular basis of human kinesin-8 function and inhibition
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9V5:4-chloranyl-2-nitro-1-(phenylsulfonyl)benzene'>9V5</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ocu|5ocu]], [[5oam|5oam]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ogc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ogc OCA], [http://pdbe.org/5ogc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ogc RCSB], [http://www.ebi.ac.uk/pdbsum/5ogc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ogc ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KI18A_HUMAN KI18A_HUMAN]] Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.<ref>PMID:17346968</ref> <ref>PMID:18267093</ref> <ref>PMID:18513970</ref> <ref>PMID:19625775</ref> [[http://www.uniprot.org/uniprot/TBB_PIG TBB_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/F2Z4C1_BOVIN F2Z4C1_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00824325]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Sus scrofa]]
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[[Category: Joseph, A P]]
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[[Category: Locke, J]]
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[[Category: Moores, C A]]
[[Category: Topf, M]]
[[Category: Topf, M]]
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[[Category: Moores, C.A]]
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[[Category: Cytoskeleton]]
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[[Category: Locke, J]]
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[[Category: Kinesin]]
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[[Category: Joseph, A.P]]
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[[Category: Motor protein]]
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[[Category: Transport protein]]

Revision as of 07:14, 25 October 2017

Molecular basis of human kinesin-8 function and inhibition

5ogc, resolution 4.80Å

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