5oht
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==GH31 glycosidase with an inhibitor bound== | |
| - | + | <StructureSection load='5oht' size='340' side='right' caption='[[5oht]], [[Resolution|resolution]] 1.87Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5oht]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OHT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9VH:[(3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)piperidin-3-yl]methanesulfonic+acid'>9VH</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfoquinovosidase Sulfoquinovosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.199 3.2.1.199] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oht OCA], [http://pdbe.org/5oht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oht RCSB], [http://www.ebi.ac.uk/pdbsum/5oht PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oht ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SQASE_ECOLI SQASE_ECOLI]] Catalyzes the hydrolysis of sulfoquinovosyl diacylglycerides (SQDG) to sulfoquinovose (SQ), which is then degraded by E.coli through the SQ Embden-Meyerhof-Parnas (SQ-EMP) sulfoglycolysis pathway as a source of carbon and sulfur. Therefore, is likely involved in the utilization of the sulfoquinovose headgroup found in ubiquitous plant sulfolipids. Is also able to hydrolyze simple sulfoquinovosides such as 1-sulfoquinovosylglycerol (SQGro). Is a retaining glycoside hydrolase, since it forms the alpha anomer of SQ (PubMed:26878550). Also exhibits some alpha-glucosidase activity against alpha-glucosyl fluoride in vitro, although natural substrates, such as alpha-glucobioses are scarcely hydrolyzed (PubMed:15294295).<ref>PMID:15294295</ref> <ref>PMID:26878550</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Sulfoquinovosidase]] | ||
| + | [[Category: Davies, G J]] | ||
[[Category: Goddard-Borger, E]] | [[Category: Goddard-Borger, E]] | ||
| - | [[Category: Davies, G.J]] | ||
| - | [[Category: Williams, S.J]] | ||
[[Category: Jin, Y]] | [[Category: Jin, Y]] | ||
| + | [[Category: Williams, S J]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: General acid-base varient]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Sulfoglycolysis]] | ||
| + | [[Category: Sulfoglycosidase]] | ||
Revision as of 21:14, 9 August 2018
GH31 glycosidase with an inhibitor bound
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