5ou8

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m (Protected "5ou8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5ou8 is ON HOLD until Paper Publication
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==Crystal structure of Glycoprotein VI in complex with collagen-peptide (GPO)5==
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<StructureSection load='5ou8' size='340' side='right' caption='[[5ou8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ou8]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OU8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OU8 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ou7|5ou7]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ou8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ou8 OCA], [http://pdbe.org/5ou8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ou8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ou8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ou8 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/GPVI_HUMAN GPVI_HUMAN]] Bleeding diathesis due to glycoprotein VI deficiency. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/GPVI_HUMAN GPVI_HUMAN]] Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.<ref>PMID:10961879</ref> <ref>PMID:18955485</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Feitsma, L J]]
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[[Category: Huizinga, E G]]
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[[Category: Blood clotting]]
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[[Category: Collagen-binding]]
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[[Category: Crp]]
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[[Category: Glycoprotein]]
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[[Category: Gpo5]]
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[[Category: Gpvi]]
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[[Category: Platelet]]
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[[Category: Platelet activation]]

Revision as of 09:59, 5 September 2018

Crystal structure of Glycoprotein VI in complex with collagen-peptide (GPO)5

5ou8, resolution 2.50Å

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