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5owe
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1010== | |
| - | + | <StructureSection load='5owe' size='340' side='right' caption='[[5owe]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5owe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OWE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B0E:1,3-bis(oxidanyl)benzo[c]chromen-6-one'>B0E</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5owe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5owe OCA], [http://pdbe.org/5owe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5owe RCSB], [http://www.ebi.ac.uk/pdbsum/5owe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5owe ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Caflisch, A]] | ||
[[Category: Spiliotopoulos, D]] | [[Category: Spiliotopoulos, D]] | ||
| - | [[Category: Caflisch, A]] | ||
[[Category: Zhu, J]] | [[Category: Zhu, J]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 07:46, 10 October 2018
Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1010
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